SCHEMBL4185231

SCHEMBL4185231

CCc1ccc(-c2ccc(-c3ccc(C(=O)C(C)(C)N4CCOCC4)cc3)c(F)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.48
ALDH1A1 P00352 3/20 0.48
MAPK1 P28482 3/20 0.48
TSHR P16473 1/20 0.48
CD274 Q9NZQ7 1/20 0.40
RARB P10826 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
FKBP1A P62942 1/20 0.39
LMNA P02545 2/20 0.38
MAPT P10636 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ALOX5AP P20292 3/20 0.38
FEN1 P39748 3/20 0.38
NPC1 O15118 1/20 0.37
MCHR1 Q99705 1/20 0.37
ERN1 O75460 1/20 0.37
APC P25054 1/20 0.36
TDP1 Q9NUW8 2/20 0.36
POLB P06746 1/20 0.35
CTDSP1 Q9GZU7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2913907 0.89 RARB (0.55) SMN1; SMN2ALDH1A1MAPK1TSHRRARB
SCHEMBL12437027 0.89 RARB (0.55) SMN1; SMN2ALDH1A1MAPK1TSHRRARB
SCHEMBL16810689 0.88 ALDH1A1 (0.51) SMN1; SMN2ALDH1A1MAPK1TSHRCD274
SCHEMBL2918327 0.88 ALDH1A1 (0.60) SMN1; SMN2ALDH1A1MAPK1TSHRHRH3
SCHEMBL2914899 0.82 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1MAPK1TSHRCD274
SCHEMBL2914565 0.77 ALDH1A1 (0.56) SMN1; SMN2ALDH1A1MAPK1TSHRHRH3
SCHEMBL306032 0.76 ALDH1A1 (0.65) SMN1; SMN2ALDH1A1MAPK1TSHRHRH3
SCHEMBL2917604 0.75 ALDH1A1 (0.63) SMN1; SMN2ALDH1A1MAPK1TSHRHRH3
SCHEMBL13657327 0.74 THRA (0.58) SMN1; SMN2ALDH1A1MAPK1TSHRRARB
SCHEMBL8070009 0.74 ALDH1A1 (0.62) SMN1; SMN2ALDH1A1MAPK1TSHRHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009125021-A1 STRUCTURED FILMS WITH A CONTROLLED TILTED MOLECULAR ORIENTATION AND SHAPE USING A DICHROIC PHOTOINITIATOR STICHTING DUTCH POLYMER INSTITUTE (NL) 2009-10-15 WO disclosed
EP-2108691-A1 Structured films with a controlled tilted molecular orientation and shape using a dichroic photoinitiator. Stichting Dutch Polymer Institute (NL) 2009-10-14 EP disclosed
WO-2006059895-A1 SWITCHABLE NARROW BAND REFLECTORS PRODUCED IN A SINGLE CURING STEP STICHTING DUTCH POLYMER INSTITUTE (NL) 2006-06-08 WO disclosed