Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.56 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | CPB1 | P15086 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1133708 | 0.85 | SLC1A3 (0.52) | SLC1A3SLC1A1DPP8DPP7LTA4H | |
| Arginine SCHEMBL4282364 | 0.84 | SLC1A3 (0.55) | SLC1A3SLC1A1DPP8DPP7ANPEP | |
| SCHEMBL453671 | 0.84 | DPP8 (0.69) | SLC1A3SLC1A1DPP8DPP7ANPEP | |
| SCHEMBL464672 | 0.84 | DPP8 (0.69) | SLC1A3SLC1A1DPP8DPP7ANPEP | |
| SCHEMBL5816135 | 0.84 | DPP8 (0.69) | SLC1A3SLC1A1DPP8DPP7ANPEP | |
| Phenylalanine SCHEMBL5062316 | 0.84 | SLC7A5 (0.59) | SLC1A3SLC1A1HTTECE1 | |
| SCHEMBL10653325 | 0.83 | DPP8 (0.60) | SLC1A3SLC1A1DPP8DPP7ANPEP | |
| Lysine SCHEMBL10720682 | 0.83 | ITGB3 (0.60) | CPB1CPB2DPP4FOLH1ITGB3 | |
| Malonic Acid SCHEMBL2698599 | 0.83 | DPP8 (0.65) | SLC1A3SLC1A1DPP8DPP7ANPEP | |
| Hydrochloric Acid SCHEMBL10653391 | 0.83 | LTA4H (0.53) | SLC1A3SLC1A1DPP8DPP7LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215986-A1 | Solution Synthesis of Peptide Cell Growth Stimulators | EPSTEIN DAVID | 2009-08-27 | — | — | US | disclosed |
| US-20070213505-A1 | Solution Synthesis of Peptide Cell Growth Stimulators | EPSTEIN DAVID | 2007-09-13 | — | — | US | disclosed |