Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TACR2 | P21452 | 7/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194752 | 0.95 | CTSK (0.51) | CTSKCTSBCTSSBCHEACHE | |
| SCHEMBL4175710 | 0.94 | CTSK (0.44) | CTSKCTSBCTSSBCHEACHE | |
| SCHEMBL4185654 | 0.90 | UTS2R (0.52) | CTSKCTSBCTSSUTS2RTACR2 | |
| SCHEMBL4180981 | 0.90 | UTS2R (0.52) | CTSKCTSBCTSSUTS2RTACR2 | |
| SCHEMBL4181100 | 0.90 | UTS2R (0.52) | CTSKCTSBCTSSUTS2RTACR2 | |
| SCHEMBL4182999 | 0.90 | UTS2R (0.52) | CTSKCTSBCTSSUTS2RTACR2 | |
| SCHEMBL4188460 | 0.88 | CTSK (0.44) | CTSKCTSBCTSSBCHEACHE | |
| SCHEMBL4192169 | 0.88 | TRPV4 (0.51) | CTSKCTSBCTSSBCHEACHE | |
| SCHEMBL4179196 | 0.87 | TACR2 (0.44) | CTSKCTSBCTSSUTS2RTACR2 | |
| SCHEMBL4183247 | 0.87 | GAA (0.41) | CTSKCTSBCTSSUTS2RRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124619-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-05-14 | — | — | US | claimed |
| EP-1869026-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105475-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | claimed |
| US-20090124619-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-05-14 | — | — | US | disclosed |
| EP-1869026-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| US-20070065483-A1 | In vivo formed matrices including natural biodegradable polysaccharides and uses thereof | SURMODICS MD, LLC | 2007-03-22 | — | — | US | disclosed |
| WO-2006105475-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124619-A1 | NOVEL COMPOUNDS | TRPV4, TRPC4, TRPV1 | CTSK 1738/4885CTSB 2311/4885CTSS 1717/4885 |
| US-20070065483-A1 | In vivo formed matrices including natural biodegradable polysaccharides and uses thereof | CD44, ADAMTS4, BMP2 | CTSK 288/4885CTSB 292/4885CTSS 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.