Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447904 | 0.74 | OPRM1 (0.47) | SMN1; SMN2LMNAOPRM1OPRD1TSHR | |
| SCHEMBL2128020 | 0.73 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAOPRM1OPRD1TSHR | |
| SCHEMBL4559299 | 0.72 | OPRD1 (0.39) | SMN1; SMN2OPRD1TSHRMAPTKCNN4 | |
| SCHEMBL3312757 | 0.69 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAOPRM1OPRD1TSHR | |
| SCHEMBL4559888 | 0.69 | CYP2B6 (0.47) | LMNAMAPTKCNN4ALDH1A1 | |
| SCHEMBL2387706 | 0.69 | MAPT (0.49) | SMN1; SMN2LMNAATMMAPTPOLB | |
| SCHEMBL27887165 | 0.68 | AKR1C3 (0.47) | SMN1; SMN2LMNATSHRMAPTPOLB | |
| SCHEMBL5196298 | 0.68 | KCNN4 (0.50) | SMN1; SMN2LMNATSHRMAPTCYP2C19 | |
| SCHEMBL12311376 | 0.67 | SMN1; SMN2 (0.42) | SMN1; SMN2TSHRMAPTPOLBKDM4E | |
| SCHEMBL10575625 | 0.67 | CYP2C19 (0.58) | SMN1; SMN2LMNATSHRMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |