Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LIPE | Q05469 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 10/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011905 | 0.94 | MAPK1 (0.69) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL1011777 | 0.92 | MAPK1 (0.51) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL1010121 | 0.85 | MAPK1 (0.69) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL14810451 | 0.81 | MAPK1 (0.53) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL1011792 | 0.79 | THRB (0.57) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL4187101 | 0.78 | MAPK1 (0.51) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL1012147 | 0.77 | MAPK1 (0.61) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL9255996 | 0.76 | MAPK1 (0.74) | MAPK1HPGDLIPELMNATHRB | |
| SCHEMBL1009491 | 0.76 | MAPK1 (0.66) | MAPK1LIPETHRBSCN9AFAAH | |
| SCHEMBL7937160 | 0.75 | LIPE (0.59) | MAPK1LIPELMNATHRBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076508-A2 | BIARYL ETHER UREA COMPOUNDS | Pfizer Products Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008047229-A2 | BIARYL ETHER UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |