Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | LIPE | Q05469 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011905 | 0.90 | MAPK1 (0.69) | MAPK1HPGDTHRBL3MBTL1LMNA | |
| SCHEMBL4190922 | 0.89 | MAPK1 (0.55) | MAPK1HPGDTHRBLMNALIPE | |
| SCHEMBL14810263 | 0.86 | MAPK1 (0.53) | MAPK1HPGDTHRBL3MBTL1LMNA | |
| SCHEMBL4187097 | 0.85 | MAPK1 (0.62) | MAPK1HPGDTHRBL3MBTL1LMNA | |
| SCHEMBL1010964 | 0.84 | THRB (0.57) | MAPK1HPGDTHRBL3MBTL1LMNA | |
| SCHEMBL1012147 | 0.82 | MAPK1 (0.61) | MAPK1HPGDTHRBLMNALIPE | |
| SCHEMBL9255996 | 0.81 | MAPK1 (0.74) | MAPK1HPGDTHRBL3MBTL1LMNA | |
| SCHEMBL1010838 | 0.81 | MAPK1 (0.66) | MAPK1HPGDTHRBL3MBTL1LIPE | |
| SCHEMBL31143143 | 0.80 | MAPT (0.57) | MAPK1HPGDTHRBLMNALIPE | |
| SCHEMBL9108593 | 0.80 | MAPT (0.57) | MAPK1HPGDTHRBLMNALIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101595102-B | Diaryl ether urea compounds | PFIZER PROD INC | 2013-08-07 | — | — | CN | disclosed |
| US-8044052-B2 | Inhibitors of fatty acid amide hydrolase; N-pyridin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide; elevate brain anandamide levels; pain, urinary incontinence, cognitive disorders, anxiety, depression, sleeping, eating, movement disorders, glaucoma, psoriasis | PFIZER INC. (US) | 2011-10-25 | — | — | US | disclosed |
| EP-2076508-B1 | BIARYL ETHER UREA COMPOUNDS | PFIZER PROD INC (US) | 2011-01-05 | — | — | EP | disclosed |
| CN-101595102-A | Diaryl ether urea compounds | PFIZER PROD INC (US) | 2009-12-02 | — | — | CN | disclosed |
| EP-2076508-A2 | BIARYL ETHER UREA COMPOUNDS | Pfizer Products Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| US-20080261941-A1 | Biaryl Ether Urea Compounds | Jazz Pharmaceuticals Therapeutics, Inc. | 2008-10-23 | — | — | US | disclosed |
| WO-2008047229-A2 | BIARYL ETHER UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261941-A1 | Biaryl Ether Urea Compounds | FAAH, FAAH2, LIPC | MAPK1 3199/4885HPGD 932/4885THRB 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.