Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | ELANE | P08246 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260518 | 0.78 | ELANE (0.61) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL13158929 | 0.76 | RAB9A (1.00) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL6851129 | 0.74 | ELANE (0.50) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL7694055 | 0.72 | RAB9A (0.64) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL7694048 | 0.71 | NPC1 (0.71) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL4258181 | 0.70 | ELANE (0.50) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL6849716 | 0.68 | NPC1 (0.45) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL4259315 | 0.68 | ELANE (0.51) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL4258103 | 0.68 | ELANE (0.51) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL4264565 | 0.68 | ELANE (0.51) | RAB9ANPC1ELANESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006116773-A2 | METHODS, COMPOSITIONS, AND COMPOUNDS FOR MODULATION OF MONOACYLGLYCEROL LIPASE, PAIN, AND STRESS-RELATED DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-11-02 | — | — | WO | disclosed |
| EP-1446125-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | Alizyme Therapeutics Limited (GB) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003020282-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-03-13 | — | — | WO | disclosed |