Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | FLI1 | Q01543 | 1/20 | 0.49 |
| ▸ | EWSR1 | Q01844 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL5533046 | 0.96 | ALDH1A1 (0.61) | ALDH1A1MAPTHPGDGSK3BPOLB | |
| SCHEMBL25424836 | 0.83 | ALDH1A1 (0.64) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL11480265 | 0.82 | GSK3B (0.80) | ALDH1A1MAPTHPGDGSK3BPOLB | |
| SCHEMBL303244 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL22367578 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL5843687 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTGSK3BPOLBSMN1; SMN2 | |
| SCHEMBL2639458 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL6014455 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL10001068 | 0.79 | GSK3B (0.61) | ALDH1A1MAPTHPGDGSK3BPOLB | |
| SCHEMBL2639461 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042888-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | BLACK LAWRENCE A | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042888-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | PTGIS, PTGS1, PTGS2 | ALDH1A1 276/4885MAPT 4825/4885HPGD 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.