Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965923 | 0.95 | ILK (0.35) | ILKHTR1AHTR2AHTR7IRAK4 | |
| SCHEMBL4197304 | 0.94 | ILK (0.40) | ILKHTR1AHTR2AHTR7NPC1 | |
| SCHEMBL4187924 | 0.89 | RAB9A (0.36) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| Acetonitrile SCHEMBL7707679 | 0.88 | RAB9A (0.35) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4192273 | 0.87 | MAPK9 (0.39) | ILKNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4197422 | 0.87 | SMN1; SMN2 (0.41) | ILKNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4186367 | 0.86 | ILK (0.37) | ILKKDM4EALDH1A1LMNAPOLB | |
| SCHEMBL4192472 | 0.86 | NPC1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4199489 | 0.85 | KMT2A (0.37) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4190183 | 0.84 | MAPT (0.40) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505083-A | — | — | 2007-03-08 | — | — | JP | claimed |
| EP-1696909-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | Applied Research Systems ARS Holding N.V. (AN) | 2006-09-06 | — | — | EP | claimed |
| WO-2005025567-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | claimed |
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |
| EP-1240164-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001047920-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-07-05 | — | — | WO | disclosed |