Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SORD | Q00796 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 5/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186367 | 0.94 | ILK (0.37) | MAPK9MAPK10ILKDPP4DPP8 | |
| SCHEMBL4187924 | 0.90 | RAB9A (0.36) | DPP4KDM4EMAPK1ALDH1A1HTT | |
| Acetonitrile SCHEMBL7707679 | 0.88 | RAB9A (0.35) | DPP4KDM4EMAPK1ALDH1A1HTT | |
| SCHEMBL4192472 | 0.88 | NPC1 (0.46) | MAPK9MAPK10ALDH1A1NPC1RAB9A | |
| SCHEMBL4197304 | 0.88 | ILK (0.40) | ILKKDM4EMAPK1ALDH1A1NPSR1 | |
| SCHEMBL4187935 | 0.87 | ILK (0.38) | ILKKDM4EMAPK1ALDH1A1NPC1 | |
| SCHEMBL4197422 | 0.87 | SMN1; SMN2 (0.41) | ILKKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7704544 | 0.87 | ILK (0.41) | ILKKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7706938 | 0.86 | KMT2A (0.37) | DPP4KDM4EALDH1A1HTTNPSR1 | |
| SCHEMBL6828604 | 0.85 | IDO1 (0.37) | DPP4DPP8DPP7KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |