Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 18/20 | 0.64 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 14/20 | 0.57 |
| ▸ | ITGAV | P06756 | 14/20 | 0.57 |
| ▸ | ITGA5 | P08648 | 14/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.57 |
| ▸ | ITGB5 | P18084 | 10/20 | 0.50 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16378072 | 0.85 | ITGB1 (0.66) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL4170016 | 0.84 | L3MBTL1 (0.79) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL4513437 | 0.84 | ITGB1 (0.50) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL8230444 | 0.84 | ITGB1 (0.50) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL4527614 | 0.81 | ITGB1 (0.62) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL6516795 | 0.77 | ITGA4 (0.66) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL4194979 | 0.76 | NLRP3 (0.59) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL8232058 | 0.76 | NLRP3 (0.59) | ITGB1ITGA4L3MBTL1ITGB3ITGAV | |
| SCHEMBL13881435 | 0.76 | PPARG (0.43) | ITGB1ITGA4L3MBTL1ITGB3ITGA2B | |
| SCHEMBL28965860 | 0.76 | PTPN1 (0.65) | L3MBTL1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024357-A2 | NEW HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | Jereni AG (DE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007131764-A2 | NEW HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2007-11-22 | — | — | WO | disclosed |