Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 5/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174123 | 0.83 | HNF4A (0.58) | TAS2R14HNF4A | |
| SCHEMBL2426967 | 0.81 | KAT6A (0.47) | BRS3XDHSLC22A12LTB4R2HDAC1 | |
| SCHEMBL6164290 | 0.80 | BRS3 (0.57) | BRS3XDHSLC22A12LTB4R2HNF4A | |
| SCHEMBL940482 | 0.79 | HSD17B10 (0.48) | TAS2R14HNF4A | |
| SCHEMBL11805019 | 0.79 | BRS3 (0.56) | BRS3XDHSLC22A12LTB4R2HNF4A | |
| SCHEMBL2744720 | 0.78 | TSHR (0.47) | BRS3XDHSLC22A12LTB4R2HNF4A | |
| SCHEMBL2744074 | 0.78 | LTB4R2 (0.46) | BRS3XDHSLC22A12LTB4R2HNF4A | |
| SCHEMBL2744830 | 0.74 | LTB4R2 (0.44) | BRS3XDHSLC22A12LTB4R2HNF4A | |
| SCHEMBL28481844 | 0.74 | ALDH1A1 (0.52) | TAS2R14 | |
| SCHEMBL28334899 | 0.74 | DDT (0.54) | HDAC1HDAC6HNF4APDK2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021328-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007131201-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2007-11-15 | — | — | WO | disclosed |