Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.71 |
| ▸ | DRD4 | P21917 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | HRH2 | P25021 | 3/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3836472 | 0.99 | HRH4 (0.70) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL3837735 | 0.85 | HRH4 (0.61) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL3405530 | 0.84 | DRD2 (0.61) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL7256287 | 0.84 | HRH4 (0.76) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL3834014 | 0.83 | HRH4 (1.00) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL4173790 | 0.83 | HRH4 (0.54) | HRH4DRD4DRD2HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL3837449 | 0.82 | HRH4 (0.53) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL4187091 | 0.81 | HRH4 (0.53) | HRH4DRD4DRD2HRH2HRH1 | |
| SCHEMBL3840090 | 0.81 | HRH4 (0.52) | HRH4DRD4DRD2HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL3834186 | 0.81 | HRH4 (0.52) | HRH4DRD4DRD2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2009-06-11 | — | — | US | claimed |
| EP-1406881-B8 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | CAMH (CA) | 2006-10-25 | — | — | EP | claimed |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2006-07-27 | — | — | US | claimed |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2005-10-06 | — | — | US | claimed |
| EP-1406881-A1 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | Neuromolecular, Inc. (CA) | 2004-04-14 | — | — | EP | claimed |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | NEUROMOLECULAR, INC. (CA) | 2003-07-17 | — | — | US | claimed |
| WO-2003000670-A1 | A11-PIPERAZINYLDIBENZO (B, F) (1, 4) OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | NEUROMOLECULAR, INC. (CA) | 2003-01-03 | — | — | WO | claimed |
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2009-06-11 | — | — | US | disclosed |
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2009-06-11 | — | — | US | disclosed |
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2009-06-11 | — | — | US | disclosed |
| EP-1406881-B8 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | CAMH (CA) | 2006-10-25 | — | — | EP | disclosed |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2006-07-27 | — | — | US | disclosed |
| EP-1593676-A1 | 8-Chloro-11-(4-(2'-hydroxyethyl)piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine of atypical anti-psychotic activity and having a low affinity for the dopamine D2 receptor | Neuromolecular, Inc. (CA) | 2005-11-09 | — | — | EP | disclosed |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2005-10-06 | — | — | US | disclosed |
| US-6890919-B2 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ (CA) | 2005-05-10 | — | — | US | disclosed |
| EP-1406881-A1 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | Neuromolecular, Inc. (CA) | 2004-04-14 | — | — | EP | disclosed |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | NEUROMOLECULAR, INC. (CA) | 2003-07-17 | — | — | US | disclosed |
| WO-2003000670-A1 | A11-PIPERAZINYLDIBENZO (B, F) (1, 4) OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | NEUROMOLECULAR, INC. (CA) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | HRH4 493/4885DRD4 11/4885DRD2 1/4885 |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | HRH4 493/4885DRD4 11/4885DRD2 1/4885 |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | HRH4 493/4885DRD4 11/4885DRD2 1/4885 |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | OPRD1, HTR1A, DRD2 | HRH4 528/4885DRD4 17/4885DRD2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.