Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | DAO | P14920 | 2/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | NAT1 | P18440 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950588 | 0.77 | CES1 (0.58) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL17038519 | 0.72 | L3MBTL1 (0.55) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL4180952 | 0.70 | CES1 (0.50) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL26259973 | 0.69 | IMPDH2 (0.55) | IMPDH2 | |
| SCHEMBL30775272 | 0.69 | CLK4 (0.51) | GSK3B | |
| SCHEMBL17038548 | 0.69 | L3MBTL1 (0.55) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL4731147 | 0.68 | PTPRC (0.54) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL1247382 | 0.67 | CES1 (1.00) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL505703 | 0.67 | CES1 (0.60) | CES1DAONSD2BCHEL3MBTL1 | |
| SCHEMBL281604 | 0.67 | CES1 (0.60) | CES1DAONSD2BCHEL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076077-A1 | Methods and Compositions for Selectin Inhibition | WYETH (US) | 2009-03-19 | — | — | US | disclosed |
| US-20090076077-A1 | Methods and Compositions for Selectin Inhibition | WYETH (US) | 2009-03-19 | — | — | US | disclosed |
| US-20090076077-A1 | Methods and Compositions for Selectin Inhibition | WYETH (US) | 2009-03-19 | — | — | US | disclosed |
| US-7465799-B2 | Methods and compositions for selectin inhibition | WYETH (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465799-B2 | Methods and compositions for selectin inhibition | WYETH (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465799-B2 | Methods and compositions for selectin inhibition | WYETH (US) | 2008-12-16 | — | — | US | disclosed |
| CN-1902179-A | Methods and compositions for selectin inhibition | WYETH CORP (US) | 2007-01-24 | — | — | CN | disclosed |
| EP-1682511-A2 | METHODS AND COMPOSITIONS FOR SELECTIN INHIBITION | Wyeth (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047257-A2 | METHODS AND COMPOSITIONS FOR SELECTIN INHIBITION | WYETH (US) | 2005-05-26 | — | — | WO | disclosed |
| US-20050101568-A1 | Methods and compositions for selectin inhibition | WYETH (US) | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101568-A1 | Methods and compositions for selectin inhibition | SELP, SELE, SELL | CES1 707/4885DAO 1610/4885NSD2 4259/4885 |
| US-20090076077-A1 | Methods and Compositions for Selectin Inhibition | SELP, SELE, SELL | CES1 883/4885DAO 1574/4885NSD2 4314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.