Sugi Predict

Sugi Predict / Compounds / SCHEMBL281604

SCHEMBL281604

SCHEMBL281604

O=C1Nc2c(F)cccc2C1=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES1 P23141 5/20 0.60
▸ DAO P14920 2/20 0.60
▸ NSD2 O96028 1/20 0.60
▸ BCHE P06276 1/20 0.60
▸ TGM2 P21980 1/20 0.55
▸ LIG1 P18858 1/20 0.55
▸ CASP3 P42574 1/20 0.48
▸ CASP2 P42575 1/20 0.48
▸ CASP7 P55210 1/20 0.48
▸ CASP6 P55212 1/20 0.48
▸ CASP8 Q14790 1/20 0.48
▸ MAOA P21397 2/20 0.47
▸ MAOB P27338 2/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ CA1 P00915 2/20 0.41
▸ CA2 P00918 2/20 0.41
▸ CA7 P43166 2/20 0.41
▸ CA9 Q16790 2/20 0.41
▸ CA12 O43570 1/20 0.41
▸ CA4 P22748 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29506270 1.00 CES1 (0.60) CES1DAONSD2BCHETGM2
SCHEMBL17038519 0.77 L3MBTL1 (0.55) CES1DAONSD2BCHETGM2
SCHEMBL2657046 0.76 LRRK2 (0.43) CES1DAONSD2BCHETGM2
SCHEMBL2657042 0.76 LRRK2 (0.43) CES1DAONSD2BCHETGM2
SCHEMBL5804729 0.76 CA1 (0.39) CES1DAONSD2BCHETGM2
SCHEMBL1247382 0.75 CES1 (1.00) CES1DAONSD2BCHETGM2
SCHEMBL3088689 0.75 DAO (1.00) CES1DAONSD2BCHELIG1
SCHEMBL5332282 0.75 CES1 (0.60) CES1DAONSD2BCHELIG1
SCHEMBL31244367 0.75 CES1 (0.60) CES1DAONSD2BCHELIG1
SCHEMBL6845708 0.75 CES1 (0.60) CES1DAONSD2BCHETGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119552328-A Substituted isatin aromatic hydrocarbon copolymer, preparation method and polymer anion exchange membrane 北京志氢科技有限公司 2025-03-04 — — CN claimed
CN-111187233-B Polysubstituted benzothiazole and derivative and synthesis method thereof 湘潭大学 2023-05-30 — — CN claimed
CN-111574426-A Diamine monomer containing isoindigo structure and black polyimide synthesized from diamine monomer 湘潭大学 2020-08-25 — — CN claimed
CN-111187233-A Polysubstituted benzothiazole and derivative and synthesis method thereof 湘潭大学 2020-05-22 — — CN claimed
US-7754895-B2 Process for the synthesis of progesterone receptor modulators WYETH LLC (US) 2010-07-13 — — US claimed
WO-2007016355-A2 PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS WYETH (US) 2007-02-08 — — WO claimed
US-20070027327-A1 Process for the synthesis of progesterone receptor modulators WYETH (US) 2007-02-01 — — US claimed
WO-2006119104-A2 PROCESS FOR PREPARING ISATINS WITH CONTROL OF SIDE-PRODUCT FORMATION WYETH (US) 2006-11-09 — — WO claimed
US-20060247442-A1 Process for preparing isatins with control of side-product formation WYETH (US) 2006-11-02 — — US claimed
US-20260083750-A1 SMALL MOLECULE INHIBITORS OF KRAS PROTEINS MERCK SHARP & DOHME LLC 2026-03-26 — — US disclosed
US-20260008791-A1 CHEMICAL COMPOUNDS BORAH INC (US) 2026-01-08 — — US disclosed
US-12421191-B2 3-hydroxyoxindole derivatives as CRHR2 antagonist RAQUALIA PHARMA INC. (JP) 2025-09-23 — — US disclosed
US-20250282781-A1 APOL1 INHIBITORS AND METHODS OF USE HERCULES CAPITAL, INC., AS AGENT 2025-09-11 — — US disclosed
US-12358932-B2 Chemical compounds BORAH, INC. (US) 2025-07-15 — — US disclosed
US-4523021-A ANTIDIABETIC AND ANTIGLACTOSEMIA AGENT IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-06-11 — — US disclosed
EP-0065407-B1 PHARMACEUTICAL SPIRO-SUCCINIMIDE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-03-13 — — EP disclosed
US-4486438-A 4-Hydroxy-3-quinoline-carboxylic acid derivatives ROUSSEL UCLAF (FR) 1984-12-04 — — US disclosed
US-4478847-A ALDOSE REDUCTASE INHIBITORS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-10-23 — — US disclosed
EP-0094184-A1 Indoline derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-11-16 — — EP disclosed
EP-0065407-A2 Pharmaceutical spiro-succinimide derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008791-A1 CHEMICAL COMPOUNDS JAK3, JAK2, JAK1 CES1 1263/4885DAO 2977/4885NSD2 2765/4885
US-20070027327-A1 Process for the synthesis of progesterone receptor modulators PGR, OXTR, PGRMC1 CES1 848/4885DAO 1196/4885NSD2 2502/4885
US-12421191-B2 3-hydroxyoxindole derivatives as CRHR2 antagonist CRHR2, CRHR1, CRH CES1 1763/4885DAO 1569/4885NSD2 4370/4885
US-20260083750-A1 SMALL MOLECULE INHIBITORS OF KRAS PROTEINS KRAS, NRAS, RASGRP1 CES1 3637/4885DAO 4759/4885NSD2 895/4885
US-20250282781-A1 APOL1 INHIBITORS AND METHODS OF USE APOL1, APOB, PON1 CES1 187/4885DAO 2323/4885NSD2 4665/4885
US-12358932-B2 Chemical compounds PDE4A, PDE4B, SYK CES1 3342/4885DAO 2347/4885NSD2 2044/4885
US-20060247442-A1 Process for preparing isatins with control of side-product formation NISCH, HASPIN, INMT CES1 453/4885DAO 86/4885NSD2 1383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.