Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Neostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 13/20 | 0.85 |
| ▸ | BCHE | P06276 | 6/20 | 0.85 |
| ▸ | LMNA | P02545 | 4/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neostigmine SCHEMBL7105728 | 0.96 | ACHE (0.87) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL11663910 | 0.94 | ACHE (0.84) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL9987576 | 0.93 | ACHE (0.86) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41903 | 0.92 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL34419 | 0.91 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 0.91 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29603805 | 0.91 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL2028206 | 0.90 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41128 | 0.90 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL16228482 | 0.90 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2197 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250375373-A1 | READY-TO-USE INJECTABLE PHARMACEUTICAL COMPOSITIONS COMPRISING NEOSTIGMINE AND GLYCOPYRROLATE | AZURITY PHARMACEUTICALS, INC. (US) | 2025-12-11 | — | — | US | claimed |
| US-20250288545-A1 | NEOSTIGMINE COMBINATIONS AND COMPOSITIONS | DAS-MG, INC. | 2025-09-18 | — | — | US | claimed |
| US-12383491-B2 | Ready-to-use injectable pharmaceutical compositions comprising neostigmine and glycopyrrolate | AZURITY PHARMACEUTICALS, INC. (US) | 2025-08-12 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| WO-2025061694-A1 | BIOCOMPATIBLE AND INJECTABLE PHOTOVOLTAIC RETINAL PROSTHESIS | AARHUS UNIVERSITET (DK) | 2025-03-27 | — | — | WO | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| WO-2025056075-A1 | MUSCLE RELAXANT ANTAGONIST FOR REVERSAL FOR BENZYLISOQUINOLINE MUSCLE RELAXANT | 杭州奥默医药股份有限公司 | 2025-03-20 | — | — | WO | claimed |
| US-12151020-B2 | Ready-to-use injectable pharmaceutical compositions comprising neostigmine and glycopyrrolate | SLAYBACK PHARMA LLC (US) | 2024-11-26 | — | — | US | claimed |
| EP-3895693-B1 | HYDROGEL COMPOSITION AND HYDROGEL LENS | PEGAVISION CORP (TW) | 2024-10-09 | — | — | EP | claimed |
| WO-1997022339-A1 | METHOD OF TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING AND MEANS FOR CARRYING OUT THE METHOD | HEDNER JAN (SE) | 1997-06-26 | — | — | WO | claimed |
| US-5624962-A | FOR OPHTHALMIC, DERMATOLOGICAL AND BADY CAVITICAL USE | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | claimed |
| EP-0694310-A1 | REVERSIBLE, THERMALLY GELLING WATER-BASE MEDICINAL COMPOSITION | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1996-01-31 | — | — | EP | claimed |
| CN-1097593-A | Aqueous drug composition having property of reversible thermosetting gelation | WAKAMOTO PHARMA CO LTD (JP) | 1995-01-25 | — | — | CN | claimed |
| EP-0462101-B1 | COMPOSITION FOR TREATING PEDICULOSIS CAPITIS | GENDERM CORP (US) | 1994-07-13 | — | — | EP | claimed |
| EP-0166724-B1 | COMPOSITION FOR TREATING PEDICULOSIS | SOFT SHEEN PRODUCTS, INC. (US) | 1990-11-22 | — | — | EP | claimed |
| EP-0166724-A1 | COMPOSITION FOR TREATING PEDICULOSIS. | SOFT SHEEN PRODUCTS INC (US) | 1986-01-08 | — | — | EP | claimed |
| WO-1985002755-A1 | METHOD AND COMPOSITION FOR TREATING PEDICULOSIS | SOFT SHEEN PRODUCTS, INC. (US) | 1985-07-04 | — | — | WO | claimed |
| US-4439427-A | Method and composition for treating pediculosis | SOFT SHEEN PRODUCTS, INC. (US) | 1984-03-27 | — | — | US | claimed |
| US-3968201-A | POLYMER | PHARMACIA AKTIEBOLAG (SW) | 1976-07-06 | — | — | US | claimed |