Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Neostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 13/20 | 1.00 |
| ▸ | BCHE | P06276 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neostigmine SCHEMBL29603805 | 1.00 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 1.00 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29618009 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL30029632 | 0.98 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL20425365 | 0.98 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41128 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL16228482 | 0.98 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7576189 | 0.97 | ACHE (0.94) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7633009 | 0.94 | ACHE (0.88) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL2028206 | 0.93 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10473 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-224242693-U | Novel stigmine injection split charging structure of glycopyrronium bromide | 广州曼翔医药有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4665351-A1 | IMPROVING GLYMPHATIC-LYMPHATIC EFFLUX | University of Rochester (US) | 2025-12-24 | — | — | EP | claimed |
| US-20250375373-A1 | READY-TO-USE INJECTABLE PHARMACEUTICAL COMPOSITIONS COMPRISING NEOSTIGMINE AND GLYCOPYRROLATE | AZURITY PHARMACEUTICALS, INC. (US) | 2025-12-11 | — | — | US | claimed |
| EP-4635489-A1 | COMPOSITION FOR PREVENTING OR TREATING SIDE EFFECTS OF CHOLINESTERASE INHIBITORS | Dr.Noah Biotech Inc. (KR) | 2025-10-22 | — | — | EP | claimed |
| US-12403262-B2 | Tamper evident assembly with RFID for syringes | FRESENIUS KABI USA, LLC (US) | 2025-09-02 | — | — | US | claimed |
| US-12390454-B2 | Use and composition for protection against organophosphorus poisoning | CLARENCE SMITH KATHLEEN E (US) | 2025-08-19 | — | — | US | claimed |
| US-12383491-B2 | Ready-to-use injectable pharmaceutical compositions comprising neostigmine and glycopyrrolate | AZURITY PHARMACEUTICALS, INC. (US) | 2025-08-12 | — | — | US | claimed |
| US-20250249185-A1 | TAMPER EVIDENT CAP WITH RFID FOR SYRINGES | FRESENIUS KABI USA, LLC | 2025-08-07 | — | — | US | claimed |
| US-4736024-A | Process for preparing salt of hyaluronic acid with a pharmaceutically active substance | FIDIA, S.P.A. (IT) | 1988-04-05 | — | — | US | claimed |
| US-4661509-A | ENZYME INHIBITORS | GORDON ARNOLD Z | 1987-04-28 | — | — | US | claimed |
| EP-0197718-A2 | New medicaments for topical use | FIDIA S.p.A. (IT) | 1986-10-15 | — | — | EP | claimed |
| US-4590166-A | WASHING WITH WATER AND ALCOHOL | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-05-20 | — | — | US | claimed |
| US-4562196-A | ANTAGONIST OF MUSCLE RELAXANTS | NELSON RESEARCH & DEVELOPMENT (US) | 1985-12-31 | — | — | US | claimed |
| EP-0152379-A2 | Process for preparing pharmaceutical compositions containing unilamellar liposomes | CIBA-GEIGY AG (CH) | 1985-08-21 | — | — | EP | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4474751-A | SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| US-4439427-A | Method and composition for treating pediculosis | SOFT SHEEN PRODUCTS, INC. (US) | 1984-03-27 | — | — | US | claimed |
| EP-0001924-B1 | PHARMACEUTICAL COMPOSITION FOR ADMINISTERING CHOLINE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1982-07-07 | — | — | EP | claimed |