Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Neostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 14/20 | 1.00 |
| ▸ | BCHE | P06276 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neostigmine SCHEMBL29618009 | 1.00 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29603805 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL34419 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL20425365 | 0.97 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL16228482 | 0.97 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL30029632 | 0.97 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7576189 | 0.95 | ACHE (0.94) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL21772308 | 0.94 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL2028206 | 0.94 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2294 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12292363-B2 | Method for preparing biological material having excellent light-transmitting property | RIKEN (JP) | 2025-05-06 | — | — | US | claimed |
| CN-119894225-A | Perovskite active layer film based on neostigmine bromide passivator, and preparation method and application thereof | 常州大学 | 2025-04-25 | — | — | CN | claimed |
| CN-118258926-A | Method for detecting glycopyrronium bromide isomer in glycopyrronium bromide neostigmine injection and quality control standard thereof | 北京阜康仁生物制药科技有限公司 | 2024-06-28 | — | — | CN | claimed |
| CN-117357476-A | New stigmine glycopyrrolate injection and preparation method thereof | 李宏 | 2024-01-09 | — | — | CN | claimed |
| CN-113277961-B | Synthesis method of bromneostigmine | 深圳市新浩瑞医药科技有限公司 | 2023-05-09 | — | — | CN | claimed |
| WO-2023059810-A1 | STENTS AND METHODS OF USE | UNIVERSITY OF CONNECTICUT (US) | 2023-04-13 | — | — | WO | claimed |
| WO-2023044463-A1 | SILK FIBROIN DERIVED BRUSH-LIKE POLYMERS | UNIVERSITY OF CONNECTICUT (US) | 2023-03-23 | — | — | WO | claimed |
| US-20220381657-A1 | METHOD FOR PREPARING BIOLOGICAL MATERIAL HAVING EXCELLENT LIGHT-TRANSMITTING PROPERTY | RIKEN (JP) | 2022-12-01 | — | — | US | claimed |
| US-11389420-B2 | Pharmaceutical compositions and methods utilizing neostigmine and an NK-1 antagonist for treating myasthenia gravis | DAS-MG, INC. (US) | 2022-07-19 | — | — | US | claimed |
| CN-113358528-B | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2022-06-17 | — | — | CN | claimed |
| WO-2000074655-A2 | DELAYED TOTAL RELEASE TWO PULSE GASTROINTESTINAL DRUG DELIVERY SYSTEM | DEXCEL PHARMA TECHNOLOGIES LTD. (IL) | 2000-12-14 | — | — | WO | claimed |
| CN-1274280-A | Delayed total release gastrointestinal delivery system | PERIO PROD LTD (IL) | 2000-11-22 | — | — | CN | claimed |
| EP-1021171-A1 | DELAYED TOTAL RELEASE GASTROINTESTINAL DRUG DELIVERY SYSTEM | Perio Products Ltd (IL) | 2000-07-26 | — | — | EP | claimed |
| WO-1999018938-A1 | DELAYED TOTAL RELEASE GASTROINTESTINAL DRUG DELIVERY SYSTEM | PERIO PRODUCTS LTD. (IL) | 1999-04-22 | — | — | WO | claimed |
| EP-0166724-B1 | COMPOSITION FOR TREATING PEDICULOSIS | SOFT SHEEN PRODUCTS, INC. (US) | 1990-11-22 | — | — | EP | claimed |
| EP-0166724-A1 | COMPOSITION FOR TREATING PEDICULOSIS. | SOFT SHEEN PRODUCTS INC (US) | 1986-01-08 | — | — | EP | claimed |
| WO-1985002755-A1 | METHOD AND COMPOSITION FOR TREATING PEDICULOSIS | SOFT SHEEN PRODUCTS, INC. (US) | 1985-07-04 | — | — | WO | claimed |
| EP-0140434-A2 | Pharmaceutical composition with systemic anticholineesterasic, agonistic-cholinergic and antimuscarinic activity | PRODOTTI FORMENTI S.r.l. (IT) | 1985-05-08 | — | — | EP | claimed |
| US-4439427-A | Method and composition for treating pediculosis | SOFT SHEEN PRODUCTS, INC. (US) | 1984-03-27 | — | — | US | claimed |
| US-4098899-A | NEOSTIGMINE BROMIDE OR NEOSTIGMINE METHYL SULFATE | SCHWARTZ GEORGE R | 1978-07-04 | — | — | US | claimed |