Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cephapirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.84 |
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | APEX1 | P27695 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CA5A | P35218 | 1/20 | 0.66 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.59 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cephapirin SCHEMBL467178 | 1.00 | NR1I2 (0.84) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL16072823 | 0.92 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL11844793 | 0.92 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL11844804 | 0.92 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL8194062 | 0.92 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL3205 | 0.92 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL9437555 | 0.91 | NR1I2 (0.98) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL151779 | 0.91 | NR1I2 (0.98) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL28932665 | 0.91 | NR1I2 (0.98) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL10275188 | 0.86 | NR1I2 (0.88) | NR1I2MAPTTDP1CYP3A4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004032899-A1 | ANTIBIOTIC FORMULATION FOR INTRAMAMMARY ADMINISTRATION IN MILKING ANIMALS | ORCHID CHEMICALS & PHARMACEUTICALS LTD. (IN) | 2004-04-22 | — | — | WO | claimed |
| US-11124758-B2 | Bacteria culture medium and applications thereof | SHANGHAI PROMOTON BIOTECHNOLOGY CO., LTD. (CN) | 2021-09-21 | — | — | US | disclosed |
| CN-110604819-A | Controlled release compositions and methods of use thereof | 拜耳新西兰有限公司 | 2019-12-24 | — | — | CN | disclosed |
| EP-3018134-B1 | BACTERIA CULTURE MEDIUM AND USE THEREOF | SHANGHAI PROMOTON BIOTECHNOLOGY CO LTD (CN) | 2018-04-04 | — | — | EP | disclosed |
| EP-3018134-A1 | BACTERIA CULTURE MEDIUM AND USE THEREOF | Shanghai Promoton Biotechnology Co., Ltd (CN) | 2016-05-11 | — | — | EP | disclosed |
| US-20160097030-A1 | Bacteria Culture Medium and Applications Thereof | NANTONG BROTH BIOTECHNOLOGY CO., LTD (CN) | 2016-04-07 | — | — | US | disclosed |
| CN-103396968-B | Bacteria culture medium and application thereof | SHANGHAI QIDONGYUAN BIOLOG SCIENT CO LTD | 2015-03-25 | — | — | CN | disclosed |
| CN-103396968-A | Bacteria culture medium and application thereof | SHANGHAI PROMOTON BIOLOG SCIENT CO LTD | 2013-11-20 | — | — | CN | disclosed |
| US-20090005448-A1 | Injection for Mastitis | NIPPON ZENYAKU KOGYO CO., LTD (JP) | 2009-01-01 | — | — | US | disclosed |
| EP-1857120-A1 | INJECTION FOR MASTITIS | Nippon Zenyaku Kogyo Co., Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
| WO-2004032899-A1 | ANTIBIOTIC FORMULATION FOR INTRAMAMMARY ADMINISTRATION IN MILKING ANIMALS | ORCHID CHEMICALS & PHARMACEUTICALS LTD. (IN) | 2004-04-22 | — | — | WO | disclosed |
| US-4322391-A | DISSOLVING IN AN ORGANIC AMIDE, HYDROCHLORIC ACID SOLUTION, PRECIPITATION AND FILTRATION | BRISTOL-MYERS COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| US-4302446-A | MICROCRYSTALLINE CISPLATEN ANTINEOPLASM AGENT | BRISTOL-MYERS COMPANY (US) | 1981-11-24 | — | — | US | disclosed |