Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cephapirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.88 |
| ▸ | ESR1 | P03372 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 8/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.75 |
| ▸ | POLB | P06746 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | APEX1 | P27695 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | CA5A | P35218 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.59 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cephapirin SCHEMBL8194062 | 0.94 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL11844804 | 0.94 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL11844793 | 0.94 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL3205 | 0.94 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL16072823 | 0.94 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL9437555 | 0.93 | NR1I2 (0.98) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL151779 | 0.93 | NR1I2 (0.98) | NR1I2ESR1PGRPTGS2KDR | |
| Cephapirin SCHEMBL28932665 | 0.93 | NR1I2 (0.98) | NR1I2ESR1PGRPTGS2KDR | |
| Cephacetrile SCHEMBL11692952 | 0.87 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR | |
| Cephacetrile SCHEMBL11851060 | 0.87 | NR1I2 (1.00) | NR1I2ESR1PGRPTGS2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210094954-A1 | PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS | XU LIFENG (US) | 2021-04-01 | — | — | US | claimed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
| US-20210094954-A1 | PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS | XU LIFENG (US) | 2021-04-01 | — | — | US | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094954-A1 | PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS | DHPS, NUDT1, DPYD | NR1I2 3339/4885ESR1 3756/4885PGR 2664/4885 |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | NR1I2 1718/4885ESR1 2278/4885PGR 3472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.