Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.65 |
| ▸ | CNR2 | P34972 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259884 | 0.90 | CNR1 (0.73) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL5258216 | 0.87 | CNR1 (0.67) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL5258790 | 0.82 | HTT (0.70) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL4194303 | 0.81 | CNR1 (0.90) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL5226089 | 0.81 | CNR1 (0.63) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL5221652 | 0.80 | CNR1 (0.55) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL5261323 | 0.80 | HTT (0.62) | CNR1CNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL4200958 | 0.80 | CNR2 (0.62) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL4190780 | 0.79 | CNR1 (1.00) | CNR1CNR2MEN1RAB9AKMT2A | |
| SCHEMBL4191608 | 0.78 | CNR1 (0.59) | CNR1CNR2MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |