Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | BCL3 | P20749 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261323 | 0.94 | HTT (0.62) | HTTALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL17554166 | 0.89 | BCL3 (0.73) | HTTALDH1A1KMT2AMEN1BCL3 | |
| SCHEMBL4191608 | 0.89 | CNR1 (0.59) | HTTALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL4204512 | 0.87 | HTT (0.55) | HTTALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL5795351 | 0.86 | KMT2A (0.63) | HTTALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL31518356 | 0.86 | KMT2A (0.63) | HTTALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL17554125 | 0.83 | BCL3 (0.74) | HTTALDH1A1KMT2ABCL3LMNA | |
| SCHEMBL4195045 | 0.83 | MEN1 (0.57) | HTTALDH1A1KMT2AMEN1CNR1 | |
| SCHEMBL5258216 | 0.83 | CNR1 (0.67) | HTTALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL4190787 | 0.82 | CNR1 (0.65) | HTTALDH1A1KMT2ACYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |