Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | BCL3 | P20749 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258790 | 0.89 | HTT (0.70) | CNR1CNR2HTTMEN1KMT2A | |
| SCHEMBL5261323 | 0.83 | HTT (0.62) | CNR1CNR2HTTMEN1KMT2A | |
| SCHEMBL17554058 | 0.81 | HTT (0.59) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL4191417 | 0.81 | CNR1 (0.82) | CNR1CNR2MEN1KMT2ARAB9A | |
| SCHEMBL17554080 | 0.80 | ALDH1A1 (0.59) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL17554166 | 0.79 | BCL3 (0.73) | HTTMEN1KMT2APPARGALDH1A1 | |
| SCHEMBL5226089 | 0.78 | CNR1 (0.63) | CNR1CNR2MEN1KMT2ARAB9A | |
| SCHEMBL10720014 | 0.78 | HPGD (0.70) | ALDH1A1SLC6A4HPGDDRD3GAA | |
| SCHEMBL4190787 | 0.78 | CNR1 (0.65) | CNR1CNR2HTTMEN1KMT2A | |
| SCHEMBL4194303 | 0.77 | CNR1 (0.90) | CNR1CNR2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |