SCHEMBL4190891

SCHEMBL4190891

C[C@@H](CC1CCCCC1)NCc1ccccc1NC(=O)NS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.43
POLB P06746 1/20 0.43
PPARG P37231 1/20 0.41
ALDH1A1 P00352 3/20 0.40
KMT2A Q03164 3/20 0.40
KDM4E B2RXH2 2/20 0.40
PKM P14618 1/20 0.40
MEN1 O00255 2/20 0.39
GAA P10253 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
USP30 Q70CQ3 2/20 0.39
THRB P10828 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39
HTR2A P28223 1/20 0.39
ADRA1A P35348 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4195114 1.00 LMNA (0.43) LMNAPOLBPPARGALDH1A1KMT2A
SCHEMBL4190720 0.92 KDM4E (0.49) LMNAPOLBPPARGALDH1A1KMT2A
SCHEMBL4195012 0.85 SMN1; SMN2 (0.47) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL4202587 0.82 RAB9A (0.47) LMNAALDH1A1KMT2AKDM4EPKM
SCHEMBL4203651 0.82 LMNA (0.38) LMNAPOLBALDH1A1KDM4EPKM
SCHEMBL4203657 0.82 LMNA (0.38) LMNAPOLBALDH1A1KDM4EPKM
SCHEMBL4709049 0.81 LMNA (0.43) LMNAPOLBPPARGALDH1A1KMT2A
SCHEMBL4197445 0.81 KMT2A (0.48) POLBALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL4196629 0.81 KMT2A (0.48) POLBALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL4195095 0.81 KMT2A (0.48) POLBALDH1A1KMT2AMEN1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 LMNA 2332/4885POLB 215/4885PPARG 1805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.