Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194335 | 0.88 | PPARG (0.45) | PPARGPPARAPPARDPSEN1PSEN2 | |
| SCHEMBL4202548 | 0.88 | PPARG (0.53) | PPARGPPARAPPARDPSEN1PSEN2 | |
| SCHEMBL4194600 | 0.83 | MCL1 (0.46) | PPARGLMNAPKMMAPT | |
| SCHEMBL3383503 | 0.82 | PKM (0.45) | PPARGPPARAPPARDPSEN1PSEN2 | |
| SCHEMBL4191214 | 0.76 | ADAM17 (0.43) | PPARGPPARAPPARDALDH1A1 | |
| SCHEMBL4187453 | 0.76 | PPARG (0.53) | PPARGPPARAPPARDPSEN1PSEN2 | |
| SCHEMBL4187136 | 0.74 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL4192840 | 0.72 | NR4A2 (0.44) | PPARGPPARAKMT2AMEN1PKM | |
| SCHEMBL4185186 | 0.71 | MCL1 (0.48) | PPARGLMNAPKMMAPT | |
| SCHEMBL4198883 | 0.71 | MCL1 (0.48) | PPARGKMT2AMEN1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572180-B1 | USE OF ALPHA-PHENYLTHIOCARBOXYLIC ACIDS WITH SERUM-GLUCOSE-LOWERING AND SERUM-LIPID-LOWERING ACTIVITY | SIGMA TAU IND FARMACEUTI (IT) | 2009-02-25 | — | — | EP | claimed |