Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | GLA | P06280 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190708 | 0.95 | USP2 (0.48) | GAAUSP2KDM4EGLARAB9A | |
| SCHEMBL4197516 | 0.91 | IRAK4 (0.39) | GAAUSP2RAB9APOLBNPC1 | |
| SCHEMBL4187928 | 0.86 | ILK (0.41) | GAAUSP2KDM4ENPSR1LMNA | |
| SCHEMBL4186367 | 0.84 | ILK (0.37) | GAAKDM4EGLANPSR1POLB | |
| SCHEMBL4194311 | 0.84 | MKNK1 (0.41) | KDM4ERAB9ALMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4195581 | 0.83 | USP2 (0.52) | GAAUSP2RAB9APOLBNPC1 | |
| SCHEMBL4192273 | 0.82 | MAPK9 (0.39) | KDM4ERAB9ANPSR1POLBNPC1 | |
| SCHEMBL4187924 | 0.82 | RAB9A (0.36) | GAAUSP2KDM4ERAB9ANPSR1 | |
| SCHEMBL4197304 | 0.82 | ILK (0.40) | GAAKDM4EGLARAB9ANPSR1 | |
| SCHEMBL6828560 | 0.82 | QPCT (0.54) | GAAKDM4EGLAPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |