Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ILK | Q13418 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192267 | 0.95 | GAA (0.46) | USP2GAAILKSMN1; SMN2RAB9A | |
| SCHEMBL4187928 | 0.91 | ILK (0.41) | USP2GAAILKALDH1A1IRAK4 | |
| SCHEMBL4197516 | 0.85 | IRAK4 (0.39) | USP2GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4195581 | 0.84 | USP2 (0.52) | USP2GAAILKSMN1; SMN2RAB9A | |
| SCHEMBL4187924 | 0.84 | RAB9A (0.36) | USP2GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4192273 | 0.84 | MAPK9 (0.39) | ILKSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL4186367 | 0.82 | ILK (0.37) | GAAILKALDH1A1KDM4EGLA | |
| SCHEMBL4192472 | 0.82 | NPC1 (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2 | |
| Acetonitrile SCHEMBL7707679 | 0.82 | RAB9A (0.35) | USP2GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4187935 | 0.81 | ILK (0.38) | ILKSMN1; SMN2RAB9ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |