Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193276 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1RAB9APPARG | |
| SCHEMBL5223641 | 0.85 | PPARG (0.52) | ALDH1A1KMT2AMEN1RAB9APPARG | |
| SCHEMBL8331088 | 0.81 | MEN1 (0.47) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL4199022 | 0.81 | CNR1 (0.64) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4188676 | 0.79 | DRD3 (0.56) | ALDH1A1KMT2AGAAHSD17B10POLB | |
| SCHEMBL5236575 | 0.77 | CNR1 (0.66) | ALDH1A1KMT2ARAB9APPARGMAPT | |
| SCHEMBL4200900 | 0.77 | BCL3 (0.61) | ALDH1A1GAATSHRPOLBKDM4E | |
| SCHEMBL4196595 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1TSHRPOLB | |
| SCHEMBL4191620 | 0.76 | POLB (0.63) | ALDH1A1KMT2AMEN1RAB9AGAA | |
| SCHEMBL5224971 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |