Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383238 | 0.80 | PPARG (0.49) | PPARGPPARDPPARAPTPN1SIRT2 | |
| SCHEMBL4187136 | 0.77 | PPARG (0.47) | PPARGPPARDPPARAPTPN1SIRT2 | |
| SCHEMBL4699232 | 0.77 | GPR84 (0.52) | PPARGPPARDPPARASIRT2FFAR1 | |
| SCHEMBL6036145 | 0.76 | PKM (0.60) | PKMCYP4F2CYP4A11NR4A2MAOB | |
| SCHEMBL6383481 | 0.74 | FFAR1 (0.52) | PPARGPPARDPPARASIRT2FFAR1 | |
| SCHEMBL25689492 | 0.74 | GPR84 (0.52) | SIRT2MAOAMAOB | |
| SCHEMBL14280732 | 0.73 | AKR1C3 (0.48) | PPARGPKMCYP4F2CYP4A11MAP4K4 | |
| SCHEMBL3383701 | 0.73 | SIRT2 (0.47) | PPARGPPARDPPARASIRT2FFAR1 | |
| SCHEMBL21331850 | 0.73 | GPR84 (0.61) | PPARGPPARDPPARAFFAR1MAOA | |
| SCHEMBL11126665 | 0.72 | SIRT2 (0.59) | SIRT2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572180-B1 | USE OF ALPHA-PHENYLTHIOCARBOXYLIC ACIDS WITH SERUM-GLUCOSE-LOWERING AND SERUM-LIPID-LOWERING ACTIVITY | SIGMA TAU IND FARMACEUTI (IT) | 2009-02-25 | — | — | EP | claimed |