SCHEMBL4193539

SCHEMBL4193539

C=CC(=O)OC(COc1ccc(-c2ccccc2)cc1)COc1c(C)cc(-c2cc(C)c(OCC(COc3ccc(-c4ccccc4)cc3)OC(=O)C=C)c(C)c2)cc1C

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
PPARG P37231 2/20 0.41
PPARA Q07869 2/20 0.41
PPARD Q03181 1/20 0.39
THRB P10828 2/20 0.39
PTGER4 P35408 4/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 3/20 0.36
RAB9A P51151 2/20 0.36
CHRNA7 P36544 1/20 0.36
LMNA P02545 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13853207 0.96 MAPT (0.39) MAPTPPARGPPARAPPARDTHRB
SCHEMBL4198624 0.94 THRB (0.44) MAPTPPARGPPARATHRBLMNA
SCHEMBL4193730 0.92 THRB (0.40) PPARGPPARATHRBSMN1; SMN2RAB9A
SCHEMBL4196014 0.91 RXRA (0.42) PPARGPPARATHRBPTGER4
SCHEMBL4186164 0.88 MAPT (0.48) MAPTTHRBSMN1; SMN2NPC1RAB9A
SCHEMBL4186231 0.88 MAPT (0.48) MAPTTHRBSMN1; SMN2NPC1RAB9A
SCHEMBL4191201 0.88 MEN1 (0.40) PPARGPPARAPPARDRAB9A
SCHEMBL14546497 0.85 THRB (0.51) MAPTPPARGPPARATHRBSMN1; SMN2
SCHEMBL4194694 0.84 THRB (0.46) MAPTTHRBLMNA
SCHEMBL13383393 0.84 MAPT (0.46) MAPTPPARGPPARAPPARDTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1627867-B1 (METH)ACRYLIC ESTER COMPOUND AND USE THEREOF MITSUI CHEMICALS INC (JP) 2016-01-20 EP disclosed
EP-1627867-B1 (METH)ACRYLIC ESTER COMPOUND AND USE THEREOF MITSUI CHEMICALS INC (JP) 2016-01-20 EP disclosed
US-7534909-B2 (Meth) acrylic ester compound and use thereof MITSUI CHEMICALS, INC. (JP) 2009-05-19 US disclosed
US-20070078198-A1 (Meth) acrylic ester compound and use thereof MITSUI CHEMICALS, INC. (JP) 2007-04-05 US disclosed
US-20070078198-A1 (Meth) acrylic ester compound and use thereof MITSUI CHEMICALS, INC. (JP) 2007-04-05 US disclosed
EP-1627867-A1 (METH)ACRYLIC ESTER COMPOUND AND USE THEREOF Mitsui Chemicals, Inc. (JP) 2006-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070078198-A1 (Meth) acrylic ester compound and use thereof METTL14, PAM, TAS2R41 MAPT 2073/4885PPARG 3465/4885PPARA 3322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.