Phenobarbital

Phenobarbital

SCHEMBL4193755

CCC1(c2ccccc2)C(=O)NC(=O)NC1=O.[H+]

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 6/20 0.77
MMP9 P14780 6/20 0.77
MMP3 P08254 3/20 0.77
KMT2A Q03164 2/20 0.66
MEN1 O00255 1/20 0.66
CYP1A2 P05177 1/20 0.66
POLB P06746 1/20 0.66
TSHR P16473 1/20 0.66
APEX1 P27695 1/20 0.66
TDP1 Q9NUW8 1/20 0.66
LMNA P02545 3/20 0.60
CYP2C19 P33261 1/20 0.54
MMP13 P45452 2/20 0.51
MMP8 P22894 1/20 0.49
CACNA1F O60840 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
HTR2A P28223 1/20 0.46
HRH1 P35367 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenobarbital SCHEMBL23494821 0.98 MMP2 (0.75) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL2592325 0.98 MMP2 (0.80) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL16583 0.98 MMP2 (0.80) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL28099657 0.98 MMP2 (0.80) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL18825042 0.98 MMP2 (0.80) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL6807467 0.96 MMP2 (0.77) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL352763 0.96 MMP2 (0.77) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL22032658 0.96 MMP2 (0.77) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL1322895 0.96 MMP2 (0.77) MMP2MMP9MMP3KMT2AMEN1
Phenobarbital SCHEMBL3475428 0.96 MMP2 (0.77) MMP2MMP9MMP3KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024048643-A1 EXOSOME PRODUCTION METHOD 東洋紡株式会社 2024-03-07 WO disclosed
US-10940235-B2 Biocompatible implants for nerve re-generation and methods of use thereof RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2021-03-09 US disclosed
US-10405963-B2 Method of producing a 3D subject specific biomimetic nerve conduit THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-09-10 US disclosed
US-20180280567-A1 BIOCOMPATIBLE IMPLANTS FOR NERVE RE-GENERATION AND METHODS OF USE THEREOF RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2018-10-04 US disclosed
EP-3283137-A1 BIOCOMPATIBLE IMPLANTS FOR NERVE RE-GENERATION AND METHODS OF USE THEREOF Rutgers, The State University of New Jersey (US) 2018-02-21 EP disclosed
US-20170135802-A1 3D PRINTED PATIENT-SPECIFIC CONDUITS FOR TREATING COMPLEX PERIPHERAL NERVE INJURY THE TRUSTEES OF PRINCETON UNIVERSITY 2017-05-18 US disclosed
WO-2016168669-A1 BIOCOMPATIBLE IMPLANTS FOR NERVE RE-GENERATION AND METHODS OF USE THEREOF RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-10-20 WO disclosed
US-20090233888-A1 TREATMENT OF DISEASE CONDITIONS THROUGH MODULATION OF HYDROGEN SULFIDE PRODUCED BY SMALL INTESTINAL BACTERIAL OVERGROWTH USC STEVENS, UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2009-09-17 US disclosed
WO-2006102536-A2 TREATMENT OF DISEASE CONDITIONS THROUGH MODULATION OF HYDROGEN SULFIDE PRODUCED BY SMALL INTESTINAL BACTERIAL OVERGROWTH UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2006-09-28 WO disclosed