SCHEMBL4196691

SCHEMBL4196691

C=C(C)C(=O)OC(C)[Si](Cl)(Cl)Cl

nearest known ligand 0.42

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.42
ALDH1A1 P00352 1/20 0.41
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL145421 0.80 TSHR (0.43) TSHRALDH1A1THRB
SCHEMBL3886364 0.80 TSHR (0.43) TSHRALDH1A1THRB
SCHEMBL1719297 0.79 TSHR (0.39) TSHRALDH1A1
SCHEMBL25329223 0.78 TSHR (0.42) TSHRALDH1A1THRB
SCHEMBL193159 0.77 ALDH1A1 (0.44) TSHRALDH1A1THRB
SCHEMBL5394202 0.77 TSHR (0.41) TSHRALDH1A1THRB
SCHEMBL523167 0.77 TSHR (0.50) TSHRALDH1A1
SCHEMBL8085168 0.75 ALDH1A1 (0.38) TSHRALDH1A1
SCHEMBL16537575 0.75 ALDH1A1 (0.43) TSHRALDH1A1
SCHEMBL6925919 0.75 ALDH1A1 (0.43) TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7638075-B2 Colored printing ink for contact lenses NOVARTIS AG (CH) 2009-12-29 US claimed
EP-1381331-B1 METHOD FOR MAKING A COLORED CONTACT LENS NOVARTIS AG (CH) 2009-03-11 EP claimed
US-6955832-B2 Colored printing ink for contact lenses NOVARTIS AG (CH) 2005-10-18 US claimed
US-20050221105-A1 Colored printing ink for contact lenses ALCON INC. (CH) 2005-10-06 US claimed
EP-1381331-A2 COLORED PRINTING INK FOR CONTACT LENSES Novartis AG (CH) 2004-01-21 EP claimed
US-20030054109-A1 Colored printing ink for contact lenses NOVARTIS AG (CH) 2003-03-20 US claimed
WO-2002074186-A2 COLORED PRINTING INK FOR CONTACT LENSES NOVARTIS AG (CH) 2002-09-26 WO claimed
CN-1947033-B Curable colored inks for making colored silicone hydrogel lenses NOVARTIS AG 2013-07-10 CN disclosed
CN-101010183-B Method for making colored silicone hydrogel contact lenses NOVARTIS AG 2012-06-27 CN disclosed
US-7638075-B2 Colored printing ink for contact lenses NOVARTIS AG (CH) 2009-12-29 US disclosed
CN-101010183-A Method for making colored silicone hydrogel contact lenses NOVARTIS AG (CH) 2007-08-01 CN disclosed
CN-1947033-A Curable colored inks for making colored silicone hydrogel lenses NOVARTIS AG (CH) 2007-04-11 CN disclosed
US-6955832-B2 Colored printing ink for contact lenses NOVARTIS AG (CH) 2005-10-18 US disclosed
US-20050221105-A1 Colored printing ink for contact lenses ALCON INC. (CH) 2005-10-06 US disclosed
EP-1216142-A4 THERMOFORMABLE OPHTHALMIC LENS NOVARTIS AG (CH) 2003-06-11 EP disclosed
US-20030054109-A1 Colored printing ink for contact lenses NOVARTIS AG (CH) 2003-03-20 US disclosed
EP-1216142-A1 THERMOFORMABLE OPHTHALMIC LENS Wesley Jessen Corporation (US) 2002-06-26 EP disclosed
WO-2001005578-A1 THERMOFORMABLE OPHTHALMIC LENS WESLEY-JESSEN CORPORATION (US) 2001-01-25 WO disclosed