SCHEMBL4196808

SCHEMBL4196808

COC(=O)c1cc(C)c(S(=O)(=O)Nc2ccccc2CN[C@@H](C)CC2CCCCC2)s1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 11/20 0.43
KDM4E B2RXH2 3/20 0.39
PKM P14618 1/20 0.39
CMA1 P23946 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
RECQL P46063 1/20 0.35
KMT2A Q03164 1/20 0.35
PI4KB Q9UBF8 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4190745 1.00 MCL1 (0.43) MCL1KDM4EPKMCMA1GAA
SCHEMBL4201643 0.99 MCL1 (0.44) MCL1KDM4EPKMCMA1GAA
SCHEMBL14343413 0.93 KDM4E (0.40) MCL1KDM4EPKM
SCHEMBL14343924 0.93 KDM4E (0.40) MCL1KDM4EPKM
SCHEMBL4190712 0.81 PPARG (0.46) KDM4EPKMGAAKMT2ASMN1; SMN2
SCHEMBL14344020 0.81 KDM4E (0.41) MCL1KDM4EPKMKMT2A
SCHEMBL4191171 0.80 CCKBR (0.45) KDM4EPKMGAAHPGDRECQL
SCHEMBL4198259 0.80 PPARG (0.47) GAAKMT2ASMN1; SMN2
SCHEMBL4193138 0.80 PKM (0.42) KDM4EPKMKMT2ASMN1; SMN2
SCHEMBL4188478 0.79 NPSR1 (0.46) KDM4EPKMKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 MCL1 1066/4885KDM4E 3328/4885PKM 1855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.