Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044245 | 0.88 | CYP19A1 (0.49) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL2423712 | 0.86 | CYP19A1 (0.55) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL1375896 | 0.86 | CYP19A1 (0.55) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL9547408 | 0.86 | CYP19A1 (0.55) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL29896215 | 0.86 | CYP19A1 (0.55) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL16230653 | 0.83 | CYP19A1 (0.56) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL27924217 | 0.83 | CYP19A1 (0.52) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL27888098 | 0.83 | CYP19A1 (0.52) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL31507922 | 0.82 | KCNA5 (0.47) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 | |
| SCHEMBL74389 | 0.81 | KIF11 (0.61) | CYP19A1CYP3A4CYP1A2LMNACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102464610-B | Preparation method of metyrapone | UNIV PEKING FOUNDER GROUP CO | 2014-07-30 | — | — | CN | claimed |
| US-8735586-B2 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | SANOFI (FR) | 2014-05-27 | — | — | US | claimed |
| EP-2173721-B1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI SA (FR) | 2011-12-28 | — | — | EP | claimed |
| EP-2173747-B1 | A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI SA (FR) | 2011-12-21 | — | — | EP | claimed |
| US-20100261909-A1 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | US | claimed |
| US-20100216988-A1 | Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles | SANOFI-AVENTIS (FR) | 2010-08-26 | — | — | US | claimed |
| EP-2173747-A1 | A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES | Sanofi-Aventis (FR) | 2010-04-14 | — | — | EP | claimed |
| EP-2173721-A1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | Sanofi-Aventis (FR) | 2010-04-14 | — | — | EP | claimed |
| WO-2009000413-A1 | A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI-AVENTIS (FR) | 2008-12-31 | — | — | WO | claimed |
| WO-2009000412-A1 | A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI AVENTIS (FR) | 2008-12-31 | — | — | WO | claimed |
| US-5939568-A | Accelerated catalysis of olefinic epoxidations | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-08-17 | — | — | US | claimed |
| WO-1998033786-A1 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-08-06 | — | — | WO | claimed |
| US-10053426-B2 | Process for the synthesis of metyrapone and alkylated metyrapone analogs | ALBEMARLE CORPORATION (US) | 2018-08-21 | — | — | US | disclosed |
| US-20170334854-A1 | One-Step Process For The Synthesis Of Alkylated Metyrapone Analogs | W. R. GRACE & CO.-CONN. | 2017-11-23 | — | — | US | disclosed |
| US-20170334854-A1 | One-Step Process For The Synthesis Of Alkylated Metyrapone Analogs | W. R. GRACE & CO.-CONN. | 2017-11-23 | — | — | US | disclosed |
| US-20170334854-A1 | One-Step Process For The Synthesis Of Alkylated Metyrapone Analogs | W. R. GRACE & CO.-CONN. | 2017-11-23 | — | — | US | disclosed |
| US-20070072096-A1 | Negative curable dye-containing composition, color filter, and method of manufacturing the same | FUJI PHOTO FILM CO., LTD. | 2007-03-29 | — | — | US | disclosed |
| US-20030035917-A1 | Image making medium | HYMAN SYDNEY (US) | 2003-02-20 | — | — | US | disclosed |
| US-5939568-A | Accelerated catalysis of olefinic epoxidations | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1998033786-A1 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261909-A1 | Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles | AZI2, NISCH, UQCRB | CYP19A1 521/4885CYP3A4 91/4885CYP1A2 20/4885 |
| US-20170334854-A1 | One-Step Process For The Synthesis Of Alkylated Metyrapone Analogs | MET, MEP1B, ABL1 | CYP19A1 602/4885CYP3A4 11/4885CYP1A2 118/4885 |
| US-10053426-B2 | Process for the synthesis of metyrapone and alkylated metyrapone analogs | MET, ABL1, CMPK1 | CYP19A1 707/4885CYP3A4 18/4885CYP1A2 107/4885 |
| US-20100216988-A1 | Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles | AZI2, NIT2, NISCH | CYP19A1 1130/4885CYP3A4 43/4885CYP1A2 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.