Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.33 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195268 | 0.86 | KDM4E (0.43) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4187170 | 0.85 | CYP1A2 (0.38) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4193769 | 0.84 | MEN1 (0.42) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4472512 | 0.84 | TSPO (0.36) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4191934 | 0.83 | KDM4E (0.43) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4188725 | 0.82 | CYP1A2 (0.43) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4193680 | 0.82 | KDM4E (0.46) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4191948 | 0.81 | MEN1 (0.45) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4479968 | 0.80 | TSPO (0.39) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4191386 | 0.78 | LMNA (0.44) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664011-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1664011-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020917-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |