Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | SORD | Q00796 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199975 | 0.89 | NPC1 (0.40) | SORDNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4198007 | 0.89 | RAB9A (0.42) | DRD4NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4197293 | 0.87 | SORD (0.40) | HTR1ADRD2HTR7DRD4DRD3 | |
| SCHEMBL4197211 | 0.87 | SCN4A (0.38) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4197998 | 0.87 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4195581 | 0.86 | USP2 (0.52) | HTR1ADRD2HTR7DRD4DRD3 | |
| SCHEMBL4964716 | 0.86 | SORD (0.35) | HTR1ADRD2HTR7DRD4DRD3 | |
| SCHEMBL4195517 | 0.86 | DPP4 (0.40) | SORDNPC1RAB9ASMN1; SMN2CYP1A2 | |
| Acetonitrile SCHEMBL6828681 | 0.84 | SORD (0.38) | HTR1ADRD2HTR7DRD4DRD3 | |
| SCHEMBL4197930 | 0.83 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |