Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199975 | 0.91 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4198007 | 0.88 | RAB9A (0.42) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4197998 | 0.88 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4195517 | 0.87 | DPP4 (0.40) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4199997 | 0.87 | HTR1A (0.42) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4195581 | 0.84 | USP2 (0.52) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4197930 | 0.84 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4197293 | 0.83 | SORD (0.40) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4194844 | 0.83 | RAB9A (0.39) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL6017501 | 0.81 | ALDH1A1 (0.37) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |
| EP-1450792-A1 | BENZAZOLE DERIVATIVES FOR THE TREATMENT OF SCLERODERMA | Applied Research Systems ARS Holding N.V. (AN) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003047570-A1 | BENZAZOLE DERIVATIVES FOR THE TREATMENT OF SCLERODERMA | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-06-12 | — | — | WO | disclosed |
| EP-1240164-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001047920-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-07-05 | — | — | WO | disclosed |