Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 5/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 12/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.44 |
| ▸ | APOB | P04114 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium SCHEMBL4200370 | 0.91 | MTTP (0.61) | MTTPSRCS1PR1S1PR3APOB | |
| SCHEMBL4200362 | 0.91 | MTTP (0.61) | MTTPSRCS1PR1S1PR3APOB | |
| Potassium Ion SCHEMBL4200248 | 0.90 | MTTP (0.70) | MTTPAPOB | |
| SCHEMBL4200400 | 0.88 | MTTP (0.70) | MTTPAPOB | |
| SCHEMBL3165562 | 0.82 | MTTP (0.75) | MTTPAPOB | |
| Potassium SCHEMBL4200253 | 0.81 | MTTP (0.74) | MTTPAPOB | |
| SCHEMBL4200245 | 0.81 | MTTP (0.74) | MTTPAPOB | |
| Water SCHEMBL4196426 | 0.81 | MTTP (0.74) | MTTPAPOB | |
| SCHEMBL4200403 | 0.81 | MTTP (0.74) | MTTPAPOB | |
| SCHEMBL4200399 | 0.81 | MTTP (0.74) | MTTPAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482368-B2 | Triamide-substituted heterobicyclic compounds | PFIZER INC (US) | 2009-01-27 | — | — | US | disclosed |