Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Nitrilotriacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.74 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentetic Acid SCHEMBL7885826 | 0.91 | GSR (0.67) | GSRARG2ARG1RNPEPCYP1A2 | |
| Edetic Acid SCHEMBL30301418 | 0.91 | GSR (0.67) | GSRARG2ARG1RNPEPCYP1A2 | |
| Edetic Acid SCHEMBL28302111 | 0.91 | GSR (0.67) | GSRARG2ARG1RNPEPCYP1A2 | |
| Edetic Acid SCHEMBL4385396 | 0.87 | GSR (0.60) | GSRARG2ARG1CYP1A2GRM8 | |
| Edetic Acid SCHEMBL4385387 | 0.87 | GSR (0.60) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL4656993 | 0.87 | GSR (0.77) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL4656997 | 0.87 | GSR (0.77) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL15303774 | 0.86 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL2802757 | 0.86 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL456381 | 0.86 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986685-A4 | VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE | MEDIVAS LLC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1986685-A2 | VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE | Medivas, LLC (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20080160089-A1 | Vaccine delivery compositions and methods of use | MEDIVAS, LLC (US) | 2008-07-03 | — | — | US | disclosed |
| WO-2007089870-A2 | VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE | MEDIVAS, LLC (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080160089-A1 | Vaccine delivery compositions and methods of use | TLR3, TLR6, TLR9 | GSR 1946/4885ARG2 796/4885ARG1 959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.