Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16379302 | 1.00 | TSHR (0.53) | TSHRCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL30423678 | 0.95 | FAAH (0.52) | TSHRCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL28910710 | 0.91 | MMP12 (0.52) | — | |
| SCHEMBL6574637 | 0.90 | TSHR (0.65) | TSHRCYP2C9CYP2C19KMT2AHPGD | |
| SCHEMBL121124 | 0.90 | TSHR (0.65) | TSHRCYP2C9CYP2C19KMT2AHPGD | |
| SCHEMBL6718014 | 0.85 | SMN1; SMN2 (0.54) | TSHRCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL27719475 | 0.85 | LMNA (0.50) | TSHRCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL15587121 | 0.85 | SMN1; SMN2 (0.54) | TSHRCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL15587059 | 0.85 | SMN1; SMN2 (0.54) | TSHRCYP2C9CYP2C19KMT2ACYP2D6 | |
| SCHEMBL1858600 | 0.85 | GRIK1 (0.54) | CYP2C9CYP2C19KMT2ACYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107912040-B | Pyrrolidine amide compounds as histone demethylase inhibitors | 基因泰克公司 | 2021-04-06 | — | — | CN | disclosed |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | GENENTECH, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | GENENTECH, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | GENENTECH, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| CN-107912040-A | Pyrrolidine Amide Compounds As Histone Demethylase Inhibitors | 基因泰克公司 | 2018-04-13 | — | — | CN | disclosed |
| US-20170312252-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | WUXI APPTEC (SHANGHAI) CO. LTD (CN) | 2017-11-02 | — | — | US | disclosed |
| US-20170312252-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | WUXI APPTEC (SHANGHAI) CO. LTD (CN) | 2017-11-02 | — | — | US | disclosed |
| US-20170312252-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | WUXI APPTEC (SHANGHAI) CO. LTD (CN) | 2017-11-02 | — | — | US | disclosed |
| EP-3204379-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | Genentech, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016057924-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016057924-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20090010958-A1 | Compositions effective in altering the perception of malodor | PATUS LTD. (IL) | 2009-01-08 | — | — | US | disclosed |
| EP-1781239-A2 | COMPOSITIONS EFFECTIVE IN ALTERING THE PERCEPTION OF MALODOR | Patus Ltd (IL) | 2007-05-09 | — | — | EP | disclosed |
| US-20070065394-A1 | Compositions effective in altering the perception of malodor | PATUS LTD. (IL) | 2007-03-22 | — | — | US | disclosed |
| WO-2005046632-A9 | COMPOSITIONS EFFECTIVE IN ALTERING THE PERCEPTION OF MALODOR | PATUS LTD (IL) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005046632-A2 | COMPOSITIONS EFFECTIVE IN ALTERING THE PERCEPTION OF MALODOR | PATUS LTD. (IL) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170312252-A1 | PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | KDM5A, KDM5C, KDM5B | TSHR 4258/4885CYP2C9 3689/4885CYP2C19 3985/4885 |
| US-10022354-B2 | Pyrrolidine amide compounds as histone demethylase inhibitors | KDM5A, KDM5C, KDM1B | TSHR 4042/4885CYP2C9 4069/4885CYP2C19 4309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.