Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723630 | 0.91 | CCR9 (0.41) | CCR9MCL1PLA2G4AALDH1A1GPR35 | |
| SCHEMBL20792840 | 0.83 | CCR9 (0.39) | CCR9MCL1GPR35 | |
| SCHEMBL4196176 | 0.80 | ENPP2 (0.39) | KDM4EALDH1A1GAA | |
| SCHEMBL4189802 | 0.78 | SIK1 (0.33) | CCNB2CCNE2CDK1FGFR1CDK4 | |
| SCHEMBL4195721 | 0.77 | CTSS (0.35) | CCNB2CCNE2CDK1FGFR1CDK4 | |
| SCHEMBL4200629 | 0.75 | CCNB2 (0.32) | CNR2CCNB2CCNE2CDK1FGFR1 | |
| SCHEMBL29437373 | 0.75 | STK17B (0.49) | CCR9KDM4EALDH1A1HPGD | |
| SCHEMBL2723441 | 0.75 | STK17B (0.49) | CCR9KDM4EALDH1A1HPGD | |
| SCHEMBL4201277 | 0.75 | CCR9 (0.36) | CCR9GPR35CDK4CCND1CCND2 | |
| SCHEMBL7504710 | 0.75 | CDK4 (0.56) | CCNB2CCNE2CDK1FGFR1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |