Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 4/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 4/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 4/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196176 | 0.81 | ENPP2 (0.39) | ENPP2HSP90B1 | |
| SCHEMBL4201281 | 0.78 | CCR9 (0.39) | FGFR1CCNB2CCNE2CDK1CDK4 | |
| SCHEMBL16057384 | 0.76 | FGFR1 (0.31) | FGFR1 | |
| SCHEMBL7504710 | 0.76 | CDK4 (0.56) | FGFR1CCNB2CCNE2CDK1CDK4 | |
| SCHEMBL4195721 | 0.75 | CTSS (0.35) | SIK1SIK2SIK3FGFR1CCNB2 | |
| SCHEMBL4200629 | 0.73 | CCNB2 (0.32) | SIK1SIK2SIK3FGFR1CCNB2 | |
| SCHEMBL4189798 | 0.73 | CYP1A2 (0.32) | — | |
| SCHEMBL29133960 | 0.73 | DCTPP1 (0.42) | CTSSCTSK | |
| SCHEMBL30661270 | 0.73 | DCTPP1 (0.42) | CTSSCTSK | |
| SCHEMBL28294705 | 0.73 | CCNB2 (0.31) | SIK1SIK2SIK3FGFR1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |