Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189802 | 0.81 | SIK1 (0.33) | ENPP2HSP90B1 | |
| SCHEMBL4201281 | 0.80 | CCR9 (0.39) | KDM4EALDH1A1GAA | |
| SCHEMBL4195721 | 0.80 | CTSS (0.35) | PDE4BHSP90B1 | |
| SCHEMBL4194383 | 0.79 | CTSS (0.35) | ENPP2HSP90B1 | |
| SCHEMBL4200629 | 0.78 | CCNB2 (0.32) | PDE4BHSP90B1 | |
| SCHEMBL7504710 | 0.77 | CDK4 (0.56) | — | |
| SCHEMBL28294705 | 0.77 | CCNB2 (0.31) | ENPP2PDE4BHSP90B1 | |
| SCHEMBL6808956 | 0.72 | CDK4 (0.60) | — | |
| SCHEMBL4187055 | 0.72 | GLO1 (0.41) | KDM4EALDH1A1KMT2ASMN1; SMN2TLR8 | |
| SCHEMBL4184836 | 0.71 | PDE4A (0.43) | SMN1; SMN2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |