Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087730 | 0.83 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTHTR6CYP19A1 | |
| SCHEMBL28563201 | 0.80 | PPARG (0.48) | ALDH1A1SMN1; SMN2MAPTAPPGALR3 | |
| SCHEMBL4203247 | 0.79 | PLG (0.49) | ALDH1A1SMN1; SMN2MAPTPLAUGALR3 | |
| SCHEMBL17044154 | 0.78 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTCYP19A1GALR3 | |
| SCHEMBL3376353 | 0.76 | NPBWR1 (0.42) | ALDH1A1SMN1; SMN2MAPTCYP19A1NOX4 | |
| SCHEMBL28573940 | 0.76 | HDAC8 (0.46) | ALDH1A1SMN1; SMN2GALR3RAB9ATSHR | |
| SCHEMBL30241534 | 0.75 | HTR6 (0.66) | HTR6APPPLAUPRKCI | |
| SCHEMBL2769024 | 0.75 | HTR6 (0.66) | HTR6APPPLAUPRKCI | |
| SCHEMBL17044148 | 0.75 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTCYP19A1GALR3 | |
| SCHEMBL30364718 | 0.75 | PLAU (0.54) | HTR6CYP19A1APPPLAUADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239861-A1 | QUINAZOLINE DERIVATIVES AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-09-24 | — | — | US | disclosed |
| CN-101365695-A | Quinazoline derivatives as anticancer agents | ASTRAZENECA AB (SE) | 2009-02-11 | — | — | CN | disclosed |
| EP-1940825-A1 | QUINAZOLINE DERIVATIVES AS ANTICANCER AGENTS | Astra Zeneca AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007034143-A1 | QUINAZOLINE DERIVATIVES AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239861-A1 | QUINAZOLINE DERIVATIVES AS ANTICANCER AGENTS | ABL1, ERBB2, CDK2 | ALDH1A1 2014/4885SMN1; SMN2 3534/4885MAPT 3072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.