SCHEMBL4201826

SCHEMBL4201826

O=C1OC2(c3cc([N+](=O)[O-])c(O)cc3Oc3cc(O)c([N+](=O)[O-])cc32)c2ccccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.59
MEN1 O00255 5/20 0.59
KMT2A Q03164 5/20 0.59
TDP1 Q9NUW8 4/20 0.59
FTO Q9C0B1 3/20 0.59
HTT P42858 2/20 0.59
RECQL P46063 2/20 0.59
BLM P54132 2/20 0.59
PRMT1 Q99873 2/20 0.59
ACE2 Q9BYF1 2/20 0.59
CYP2C19 P33261 2/20 0.59
HPGD P15428 1/20 0.59
SMAD3 P84022 1/20 0.59
GNG2 P59768 1/20 0.49
GNB1 P62873 1/20 0.49
LMNA P02545 5/20 0.48
USP2 O75604 2/20 0.48
ALDH1A1 P00352 2/20 0.48
CYP3A4 P08684 3/20 0.46
POLB P06746 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4960577 0.85 MAPT (0.62) MAPTMEN1KMT2ATDP1FTO
SCHEMBL31620935 0.84 MAPT (0.71) MAPTMEN1KMT2ATDP1FTO
Fluorescein SCHEMBL27917033 0.81 FTO (0.67) MAPTMEN1KMT2ATDP1FTO
SCHEMBL4959116 0.80 LMNA (0.64) MAPTMEN1KMT2ATDP1GNG2
SCHEMBL29367262 0.79 MAPT (0.64) MAPTMEN1KMT2ATDP1FTO
SCHEMBL499184 0.79 MAPT (0.64) MAPTMEN1KMT2ATDP1FTO
SCHEMBL499135 0.79 MAPT (0.64) MAPTMEN1KMT2ATDP1FTO
Dichlorofluorescein SCHEMBL30606648 0.79 MAPT (0.64) MAPTMEN1KMT2ATDP1FTO
SCHEMBL408340 0.79 MAPT (0.64) MAPTMEN1KMT2ATDP1FTO
SCHEMBL30218785 0.79 MAPT (0.64) MAPTMEN1KMT2ATDP1FTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118215417-A Antibacterial multi-layer fabric medium and preparation method thereof 乔治华盛顿大学 2024-06-18 CN disclosed
CN-112368027-A Absorbent biophotonic fiber systems 克洛克斯科技公司 2021-02-12 CN disclosed
US-10130706-B2 Biophotonic materials and uses thereof KLOX TECHNOLOGIES INC. (CA) 2018-11-20 US disclosed
CN-108066896-A Phototherapy device and method 克洛克斯科技公司 2018-05-25 CN disclosed
CN-107669507-A Bio-photon composition, kit and method 克洛克斯科技公司 2018-02-09 CN disclosed
CN-104379213-B Phototherapy device and method 克洛克斯科技公司 2018-01-02 CN disclosed
CN-104394888-A Compositions and methods for biophotonic bone reconstruction KLOX TECHNOLOGIES INC 2015-03-04 CN disclosed
CN-104379213-A Phototherapy device and method KLOX TECHNOLOGIES INC 2015-02-25 CN disclosed
US-20090192209-A1 Extended treatment of tumors through vessel occlusion with light activated drugs LIGHT SCIENCES ONCOLOGY, INC. (US) 2009-07-30 US disclosed
US-7060695-B2 Method to prevent vision loss QLT, INC. (CA) 2006-06-13 US disclosed
US-20060039965-A1 Drug delivery system for hydrophobic drugs QLT INC. (CA) 2006-02-23 US disclosed
US-6599891-B2 Administering to the subject an amount of a photosensitizer (PS) sufficient to allow said photosensitizer to localize in lesion; irradiating said lesion with light having a wavelength absorbed by said PS QLT INC. (CA) 2003-07-29 US disclosed
US-20020183302-A1 Method to prevent vision loss TECHNOLAS PERFECT VISION GMBH (DE) 2002-12-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020183302-A1 Method to prevent vision loss VEGFA, ALDH1A2, PDE6C MAPT 2446/4885MEN1 3014/4885KMT2A 3251/4885
US-20090192209-A1 Extended treatment of tumors through vessel occlusion with light activated drugs PTGIR, TEK, FLT4 MAPT 2414/4885MEN1 1206/4885KMT2A 3558/4885
US-20060039965-A1 Drug delivery system for hydrophobic drugs LIPA, ABCG2, NSF MAPT 437/4885MEN1 1835/4885KMT2A 3805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.