Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206058 | 0.94 | ACHE (0.43) | ACHESLC6A3DRD2DRD4CCR3 | |
| Hydrochloric Acid SCHEMBL4204675 | 0.93 | ACHE (0.42) | ACHESLC6A3DRD2DRD4 | |
| SCHEMBL4207762 | 0.85 | ACHE (0.42) | ACHESLC6A3CCR3 | |
| SCHEMBL4206936 | 0.82 | ACHE (0.46) | ACHESLC6A3DRD2DRD4CCR3 | |
| Hydrochloric Acid SCHEMBL4203851 | 0.81 | ACHE (0.46) | ACHEDRD2DRD4CCR3 | |
| Hydrochloric Acid SCHEMBL18818465 | 0.81 | ACHE (0.41) | ACHEDRD2DRD4 | |
| SCHEMBL4209827 | 0.80 | ACHE (0.45) | ACHEDRD2DRD4CCR3 | |
| Hydrochloric Acid SCHEMBL4207910 | 0.79 | ACHE (0.44) | ACHEDRD2DRD4CCR3 | |
| SCHEMBL699787 | 0.78 | CCR3 (0.46) | ACHECCR3 | |
| Hydrochloric Acid SCHEMBL4842406 | 0.78 | CCR3 (0.45) | ACHECCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137629-A1 | Sigma receptor binding agent containing indanone derivative | IIMURA YOICHI | 2009-05-28 | — | — | US | claimed |
| US-20050107432-A1 | Sigma receptor binder containing indanone derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-05-19 | — | — | US | claimed |
| EP-1468684-A1 | SIGMA RECEPTOR BINDER CONTAINING INDANONE DERIVATIVE | Eisai Co., Ltd. (JP) | 2004-10-20 | — | — | EP | claimed |
| EP-1157989-B1 | FLUORIDES OF 4-SUBSTITUTED PIPERIDINE DERIVATIVES | EISAI CO LTD (JP) | 2004-09-22 | — | — | EP | claimed |
| US-6677330-B1 | ACETYLCHOLINESTERASE INHIBITORS; TREATING ALZHEIMER*S DISEASE, ATTENTION DEFICIT, HYPERACTIVITY AND BRAIN DISORDERS | EISAI CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| EP-1157989-A1 | FLUORIDES OF 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-28 | — | — | EP | claimed |
| US-20090137629-A1 | Sigma receptor binding agent containing indanone derivative | IIMURA YOICHI | 2009-05-28 | — | — | US | disclosed |
| US-20050107432-A1 | Sigma receptor binder containing indanone derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-05-19 | — | — | US | disclosed |
| EP-1468684-A1 | SIGMA RECEPTOR BINDER CONTAINING INDANONE DERIVATIVE | Eisai Co., Ltd. (JP) | 2004-10-20 | — | — | EP | disclosed |
| EP-1157989-B1 | FLUORIDES OF 4-SUBSTITUTED PIPERIDINE DERIVATIVES | EISAI CO LTD (JP) | 2004-09-22 | — | — | EP | disclosed |
| US-6677330-B1 | ACETYLCHOLINESTERASE INHIBITORS; TREATING ALZHEIMER*S DISEASE, ATTENTION DEFICIT, HYPERACTIVITY AND BRAIN DISORDERS | EISAI CO., LTD. (JP) | 2004-01-13 | — | — | US | disclosed |
| EP-1157989-A1 | FLUORIDES OF 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137629-A1 | Sigma receptor binding agent containing indanone derivative | SIGMAR1, TMEM97, OPRK1 | ACHE 608/4885SLC6A3 59/4885DRD2 140/4885 |
| US-20050107432-A1 | Sigma receptor binder containing indanone derivative | SIGMAR1, OPRK1, TMEM97 | ACHE 2667/4885SLC6A3 162/4885DRD2 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.