Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.79 |
| ▸ | GMNN | O75496 | 1/20 | 0.79 |
| ▸ | TTR | P02766 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.79 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.79 |
| ▸ | DHODH | Q02127 | 1/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.79 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niflumic Acid SCHEMBL4886924 | 0.88 | DHODH (1.00) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| Niflumic Acid SCHEMBL24706 | 0.88 | DHODH (1.00) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| Niflumic Acid SCHEMBL29364001 | 0.88 | DHODH (1.00) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| Niflumic Acid SCHEMBL29373503 | 0.88 | DHODH (1.00) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL5953848 | 0.88 | LMNA (0.78) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| Niflumic Acid SCHEMBL10435526 | 0.87 | LMNA (0.97) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL12608890 | 0.87 | LMNA (0.79) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| Niflumic Acid SCHEMBL8925125 | 0.87 | DHODH (0.97) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL25392363 | 0.85 | LMNA (0.76) | LMNAMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL22492824 | 0.84 | LMNA (0.78) | LMNAMEN1ALDH1A1KMT2ATEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613318-A4 | COMPOUNDS AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORP (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20060094714-A1 | Compounds and their use to treat diabetes and related disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-05-04 | — | — | US | disclosed |
| EP-1613318-A2 | COMPOUNDS AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087880-A2 | COMPOUNDS AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |
| EP-1054868-B1 | SUBSTITUTED PYRIDINO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ORTHO MCNEIL PHARM INC (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6218396-B1 | SELECTIVELY INHIBITS BINDING TO AN ADRENERGIC RECEPTOR | ORTH-MCNEIL PHARMACEUTICAL, INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1054868-A1 | NOVEL SUBSTITUTED PYRIDINO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042448-A1 | NOVEL SUBSTITUTED PYRIDINO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-08-26 | — | — | WO | disclosed |
| US-4546106-A | ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1985-10-08 | — | — | US | disclosed |
| US-4355034-A | Ethenyl derivatives of mercaptoalkylpyridines as anti-inflammatory agents | MERCK & CO., INC. (US) | 1982-10-19 | — | — | US | disclosed |
| US-4217352-A | ANTIARTHRITIC AGENT | MERCK & CO., INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4212976-A | ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4144342-A | ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. (US) | 1979-03-13 | — | — | US | disclosed |
| US-4061759-A | ANTIINFLAMMATORY, ARTHRITIS | MERCK & CO., INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-4057637-A | RHEUMATOID ARTHRITIS | MERCK & CO., INC. (US) | 1977-11-08 | — | — | US | disclosed |
| US-3971797-A | ANTIARTHRITIC | MERCK & CO., INC. (US) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094714-A1 | Compounds and their use to treat diabetes and related disorders | IAPP, SLC5A2, SLC5A1 | LMNA 2697/4885MEN1 894/4885ALDH1A1 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.