Terephthalic Acid

Terephthalic Acid

SCHEMBL4204274

O=C(O)c1ccc(C(=O)O)cc1.O=C1OC(=O)c2ccccc21

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.64
TDP1 Q9NUW8 1/20 0.64
TSHR P16473 2/20 0.56
DAO P14920 1/20 0.56
NAPRT Q6XQN6 1/20 0.56
CA12 O43570 2/20 0.55
CA1 P00915 2/20 0.55
CA2 P00918 1/20 0.55
CA9 Q16790 1/20 0.55
SCN2A Q99250 1/20 0.55
TP53 P04637 1/20 0.55
SRD5A2 P31213 2/20 0.54
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54
TTR P02766 1/20 0.53
HSD17B10 Q99714 1/20 0.53
PTPRC P08575 2/20 0.52
GAA P10253 1/20 0.51
PKM P14618 1/20 0.51
CA4 P22748 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalic Anhydride SCHEMBL5450495 0.95 TSHR (0.64) ALOX15TDP1TSHRDAONAPRT
Terephthalic Acid SCHEMBL1292728 0.90 TTR (0.55) ALOX15TDP1TSHRDAONAPRT
Phthalic Anhydride SCHEMBL28856609 0.89 ALOX15 (0.61) ALOX15TDP1TSHRDAONAPRT
Phthalic Anhydride SCHEMBL5930931 0.88 TTR (0.67) ALOX15TDP1CA12CA1CA2
Phthalic Anhydride SCHEMBL8676881 0.86 TSHR (0.52) ALOX15TDP1TSHRDAONAPRT
Benzoic Acid SCHEMBL27945375 0.86 TTR (0.59) ALOX15TDP1TSHRDAONAPRT
Isophthalic Acid SCHEMBL4990367 0.85 TDP1 (0.56) ALOX15TDP1TSHRDAONAPRT
Phthalic Anhydride SCHEMBL28279463 0.85 TDP1 (0.88) ALOX15TDP1TSHRCA1CA2
Phthalic Anhydride SCHEMBL28044866 0.83 TDP1 (0.74) ALOX15TDP1TSHRCA12CA1
Phthalic Anhydride SCHEMBL10392547 0.83 TSHR (0.48) ALOX15TDP1TSHRDAONAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10995155-B2 Cellulose composite materials and methods of making and using the same GP CELLULOSE GMBH (CH) 2021-05-04 US claimed
US-20180312610-A1 NOVEL CELLULOSE COMPOSITE MATERIALS AND METHODS OF MAKING AND USING THE SAME GP CELLULOSE GMBH (CH) 2018-11-01 US claimed
EP-3362485-A1 NOVEL CELLULOSE COMPOSITE MATERIALS AND METHODS OF MAKING AND USING THE SAME GP Cellulose GmbH (CH) 2018-08-22 EP claimed
WO-2017066499-A1 NOVEL CELLULOSE COMPOSITE MATERIALS AND METHODS OF MAKING AND USING THE SAME GP CELLULOSE GMBH (CH) 2017-04-20 WO claimed
US-5096960-A Substituting aromatic triacid component with a maleinized fatty acid, reduced consolvent content WESTVACO CORPORATION (US) 1992-03-17 US claimed
US-10995155-B2 Cellulose composite materials and methods of making and using the same GP CELLULOSE GMBH (CH) 2021-05-04 US disclosed
CN-109983047-A Bio-renewable high-performance polyester polyalcohol PTT全球化学公众有限公司 2019-07-05 CN disclosed
US-20180312610-A1 NOVEL CELLULOSE COMPOSITE MATERIALS AND METHODS OF MAKING AND USING THE SAME GP CELLULOSE GMBH (CH) 2018-11-01 US disclosed
EP-3140341-B1 METHOD USING ZIRCONIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS BASF COATINGS GMBH (DE) 2018-08-29 EP disclosed
US-10059789-B2 Method using titanium catalyst for producing carbamate-functional materials BASF COATINGS GMBH (DE) 2018-08-28 US disclosed
EP-3362485-A1 NOVEL CELLULOSE COMPOSITE MATERIALS AND METHODS OF MAKING AND USING THE SAME GP Cellulose GmbH (CH) 2018-08-22 EP disclosed
US-20170183436-A1 METHOD USING ZIRCONIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS BASF COATINGS GMBH (DE) 2017-06-29 US disclosed
US-9376378-B2 Method using zirconium catalyst for producing carbamate-functional materials BASF COATINGS GMBH (DE) 2016-06-28 US disclosed
US-9334234-B2 Method using titanium catalyst for producing carbamate-functional materials BASF COATINGS GMBH (DE) 2016-05-10 US disclosed
US-20150321999-A1 METHOD USING TITANIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS BASF COATINGS GMBH (DE) 2015-11-12 US disclosed
WO-2015169545-A1 METHOD USING TITANIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS BASF COATINGS GMBH (DE) 2015-11-12 WO disclosed
US-20150321998-A1 METHOD USING ZIRCONIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS BASF COATINGS GMBH (DE) 2015-11-12 US disclosed
US-20090004457-A1 POLYMER FOAM COMPOSITE CONTAINING HOLLOW PARTICLES AND PROCESS FOR PREPARING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2009-01-01 US disclosed
EP-1341051-B1 Toner for electrostatic image development DAINIPPON INK & CHEMICALS (JP) 2006-04-19 EP disclosed
US-5525645-A Resin composition for optical molding ASAHI DENKA KOGYO K.K. (JP) 1996-06-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10059789-B2 Method using titanium catalyst for producing carbamate-functional materials CTSH, CTSF, CAT ALOX15 1852/4885TDP1 1162/4885TSHR 826/4885
US-20170183436-A1 METHOD USING ZIRCONIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS KAT5, KAT7, KAT6A ALOX15 1127/4885TDP1 2784/4885TSHR 3519/4885
US-20150321999-A1 METHOD USING TITANIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS CTSH, CTSF, CAT ALOX15 1852/4885TDP1 1162/4885TSHR 826/4885
US-20150321998-A1 METHOD USING ZIRCONIUM CATALYST FOR PRODUCING CARBAMATE-FUNCTIONAL MATERIALS KAT5, KAT2A, KAT6A ALOX15 886/4885TDP1 2857/4885TSHR 3610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.