Catalpol

Catalpol

SCHEMBL420515

OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@H](O)[C@@H]4O[C@]4(CO)[C@@H]23)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HSP90AA1 P07900 9/20 0.65
▸ XDH P47989 1/20 0.64
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ POLB P06746 1/20 0.42
▸ CTDSP1 Q9GZU7 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.37
▸ GLA P06280 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ SYNJ2 O15056 1/20 0.36
▸ PTPN1 P18031 1/20 0.35
▸ TYR P14679 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Catalpol SCHEMBL17231369 1.00 HSP90AA1 (0.65) HSP90AA1XDHL3MBTL1MEN1KMT2A
Catalpol SCHEMBL29374095 1.00 HSP90AA1 (0.65) HSP90AA1XDHL3MBTL1MEN1KMT2A
SCHEMBL29478493 0.94 HSP90AA1 (0.59) HSP90AA1XDHL3MBTL1MEN1KMT2A
SCHEMBL31345813 0.91 HSP90AA1 (0.70) HSP90AA1XDHL3MBTL1MEN1KMT2A
SCHEMBL20714336 0.91 HSP90AA1 (0.55) HSP90AA1XDHL3MBTL1MEN1KMT2A
SCHEMBL20382966 0.91 HSP90AA1 (0.55) HSP90AA1XDHL3MBTL1MEN1KMT2A
Methylcatalpol SCHEMBL29425882 0.88 HSP90AA1 (0.67) HSP90AA1XDHL3MBTL1MEN1KMT2A
SCHEMBL10307818 0.85 L3MBTL1 (0.53) HSP90AA1XDHL3MBTL1MEN1KMT2A
Catalposide SCHEMBL419598 0.79 HSP90AA1 (1.00) HSP90AA1XDHL3MBTL1MEN1KMT2A
SCHEMBL20382967 0.78 HSP90AA1 (0.43) HSP90AA1XDHL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2994 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117205226-B Application of catalpol in preparation of medicines for preventing and treating schizophrenia and relieving olanzapine glycolipid metabolism side effects SOUTHWEST UNIVERSITY (CN) 2026-05-26 — — CN claimed
CN-122075542-A Application of catalpol and mesenchymal stem cells in preparation of medicines for treating hepatic fibrosis — 2026-05-26 — — CN claimed
CN-122075609-A Preparation method and application of composite bacterium synchronous fermentation rehmannia with bowel relaxing function — 2026-05-26 — — CN claimed
CN-121570564-A Traditional Chinese medicine pessary for treating cervicitis diseases and preparation method and application thereof 长春中医药大学附属医院(吉林省中医院) 2026-02-27 — — CN claimed
EP-4694699-A2 COMPOSITIONS AND METHODS OF CONTROLLING MAMMALIAN SATIETY VitaKey Inc. (US) 2026-02-18 — — EP claimed
CN-120195297-A Fingerprint detection method of yellow land yin nourishing particles 辽宁沃华康辰医药有限公司 2025-06-24 — — CN claimed
CN-120131684-A Pharmaceutical composition for treating type 2 diabetes and application thereof 华北理工大学 2025-06-13 — — CN claimed
CN-120118139-A Catalpol derivative, synthesis process and application 华东理工大学 2025-06-10 — — CN claimed
EP-4379068-B1 IRIDOID OR SECO-IRIDOID DERIVATIVES AND THEIR USE IN A TANNING PROCESS INSTITUT NAT DES SCIENCES APPLIQUEES DE ROUEN (FR) 2025-06-04 — — EP claimed
CN-116350681-B Herba Ixeritis Denticulatae extract with heart failure treating and/or preventing effects, and its preparation method and application 珠海市藤栢医药有限公司 2025-05-16 — — CN claimed
CN-1631404-A Medical application of rehmannia root extractive in resisting asthma and allergy LUO HESHENG (CN) 2005-06-29 — — CN claimed
CN-1606930-A Radiation proof health food for improving acuity of vision and its production method WANG ENPING (CN) 2005-04-20 — — CN claimed
CN-1572311-A Prepared licorice granule and its preparation method INNER MONGOLIA YITAI PHARMACEU (CN) 2005-02-02 — — CN claimed
US-20050019435-A1 Method of treating non-insulin dependent diabetes mellitus and related complications YOUNG JEFFREY (US) 2005-01-27 — — US claimed
CN-1187998-A Chinese medicine dried pieces of fresh rehmannia root and its preparation process BEIJING COMPREHENSIVE INST OF (CN) 1998-07-22 — — CN claimed
CN-1171212-A Sun Cola and its preparation process WANG ZHONG (CN) 1998-01-28 — — CN claimed
US-5589182-A AQUEOUS EXTRACTS OF TISSUE OF SPECIFIC CHINESE PLANTS AND HERBS TASHIRO RENKI (JP) 1996-12-31 — — US claimed
CN-1082895-A The Pharmaceutical composition that treatment hepatitis B virus (HBV) infects CHOONGWAE PHARMA CO LTD (KR) 1994-03-02 — — CN claimed
EP-0045837-B1 REACTIVE DERIVATIVES OF 3-OXA-BICYCLO(4.3.0)-NON-1-ENE-9-ONE, PROCESS FOR THEIR PREPARATION AND THEIR USE Dr. Willmar Schwabe GmbH & Co. (DE) 1984-09-19 — — EP claimed
EP-0045837-A1 Reactive derivatives of 3-oxa-bicyclo(4.3.0)-non-1-ene-9-one, process for their preparation and their use Dr. Willmar Schwabe GmbH & Co. (DE) 1982-02-17 — — EP claimed
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