Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037069 | 0.69 | ALDH1A1 (0.40) | KDM4EALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL3567094 | 0.66 | ALDH1A1 (0.40) | KDM4EALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL3567092 | 0.62 | USP2 (0.45) | KDM4EALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL10005374 | 0.59 | TLR8 (0.71) | KDM4EALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL7397442 | 0.59 | TP53 (0.65) | KDM4EALDH1A1LMNATSHRMAPT | |
| SCHEMBL28819557 | 0.58 | PTAFR (0.46) | ALDH1A1LMNATSHRMAPTSMN1; SMN2 | |
| SCHEMBL7390863 | 0.58 | TP53 (0.64) | KDM4EALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7391995 | 0.58 | TP53 (0.64) | KDM4EALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7393259 | 0.58 | KDM4E (0.64) | KDM4EALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL7389782 | 0.57 | KDM4E (0.61) | KDM4EALDH1A1LMNATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |